The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

348 amino acids

MIDTIEKEDTIISEEEAAQYDRQIRLWGLDAQKRLRGSRVLLVGLRGLGAEVAKNLILAGVKGLTLLDHEQVTEESRRAQFLIPVDADGQNHAQASLERAQFLNPMVEVKADTEPVESKPDDFFFQFDAVCLTRCSRDLMVRVDQLCASRNIKVFCGDVYGYNGYMFSDLGQEYHYVEEKPKVVKGSNEANDGPEAKKPKIDPNETTMVKKTISFCSLKEALEVDWTTEKAKSSLKRIPADYFLLQVLLKFRTDKGRDPQPDSFAEDSQLLLQIRDDVLETMGLSSDLLPNTFVSYCFSEMSPVCAVVGGVLGQEIVKALSQRDAPHRNFFFFDGLKGSGVVDYFSSK

39.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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