Description
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.
Sequence
MLPTASSKRRTFAARYFTRSKSLVMGEQSRSPGRPLVPHKLGPVLKAGWLRKQRSIMKNWQQRWFVLRGDQLFYYKDKDESKPQGFISLQGTQVTELLPDPEDPGKHLFEITPGGATEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGRGIFGQRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYICKFLDEVQAHSDVNKMSVQNLATVFGPNILRPQIEDPVTIMEGTSLVQHLMTVLIRKHGQLFAATSLEEPASPHGTVEWGSEEVTRDHRGEPGSPGLPTHRTSSLDGPAAAVLSRTSPPRLGSQTGPAATSPGKKMHTLPVWKSSFRQQGSRSESPKGVNSSLEVPIISSGGNWLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPPSSQFSSTASVASTSWSVASSSREASVSSCTACRASNSSACSSLHTEWALEPSPLPSSSEGHQSPDLGHSLDEPCVGSGSSEPNDPGSPTQAHVRRCRALQGQVAELRAELCQQRTEYKRSLKSIEEGSADLRKQMSRLEEELDQERKKYAMLEIKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTTGTKGSRAPE
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
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Protein synthesis service