GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.

960 amino acids

MLPRLFLTILPVCSPSISNKTSKKFRDAHANHVFLFEMDLNNTLSFFGKQLKLDTEEEISKVIDQIRKHLNLEVLDFRGNTLSVLAGKLIAESLKTRRELKECIWSDMFTGRLKDEIPLVLDALGEALTASGCRLTTLDLSDNAFGAGLSTSLYNFLQSPALYSLENLILNNNGLGLAGKTVGKALCSLIDASKKAGTPLKLKKFVCGRNRLEVESTIALSDAFIKLGTLEEIRLPQNGIRDDGIIALAEAFRMNKKLRIIDINDNFCCPEGAIQISEVLSDLQFIEVLDLGDCVCDDPGVLAIIAELDKINRDCLKKVVLSGNNITSDVIDEIGACFNSPKMCHVKVDISVNMFGKDFDSAKARHGKGNIDFGRRGDDELLSSDEEEEQGAEDASMEEDAFNTSRETVIDRSNLHEASADEMMNDLMNKGFGCMKIEDNQQNSNGNGMVSFLDKSLKLDTAESAEPVVKVIAAASSMKALELRGNTLGIAAGNVIAKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKDLLESPSSFSLEVLKLNNNGLGIGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGAHALAATFKALETVEWFDVRQNGIHEEGIRALVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLESWPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQKWSKFDGLTPKPVLHIHTNSFGDEFSDVAGMAPENVNVGDEDDDLGSLDGDQEEYNSKSSDSEDADLDDDDEDDDEEAEIQIIDNGESQLKLAMDRIDRLDIDFESRFQEDTARVILQLSAPLKSCKMSEPALQRAIEVAENIVRRVESVKRNPIPATTQLVNNIVAQCAGTGVKAETDWGYGADPQVISRLFSELVARGHFKLELALLQRFFPSQ

105.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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