Multifunctional enzyme that catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA), the NAD-dependent ring dehydrogenation of precorrin-2 to sirohydrochlorin and finally, the ferrochelation of sirohydrochlorin to yield siroheme.

In the C-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.

515 amino acids

MQLGRHNSGSIKKRLEMYILSIISASLDYKSAAIDIRERFSYTSTRIREILRRIKAADGVSGAVLLCTCNRTELYISGDNIENMNPALLLCQLSGEEDHKSLMTLFSIRHDSEAIFHLMEVACGLQSMVLFEDRVITQVKNAAAISREEKTIDSTLETLFRLCITAAKKAKTEIKVKAVPTSAAERAITELSKKYCFTDKRILVIGNGEIGRLCCKKLIELGAEITITLRKYKHGEIIIPVGCNTIPYDEREEVLPLSDVVISATTSPHFTITYDMIEKLERKPEIFVDLALPRDIESSISNFTGVELYNLDRFYTDYSVLNQKEVSKIREIINHFILQFEKWKDYREEAAFTKIPDLHNDTLYGRFPLFIDLSGKKVLVVGGGEIATRRVKTLLRFGADIYLVAPHLTSELQEMLNCKLINYREGYYESQDIQNMFLVIAATNDRETNHKVYLDAKEKGIQMSIADCREECSFYFPAIFEFDGIVGGLVSQNGDNHSLVKSVAEQIRKIGQATD

58.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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