NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Belongs to the complex I subunit 2 family.

469 amino acids

MNPEEAMRPLLMASEMMMFGAGLVALIAGSFLRRQRQWWVGVMAAAAQVGVIGVAVVQMVGPDQMAFEGAFSVDTATGVARIACAAGLLLIWAVAGAEMRASPREAETYALLMFSATGVLVLAGAEDLLLLVAGYFLASIPLYGLVGLARSAAAAEAAMKAYLMGALFGILLMLGVTILYGLTGATRYPQLAMTLSGAPAVAVAAGVVGVLAGLMFEAGGVPAHFWVPDAAQGANATAATFLTTVPKIGALVALYRLTTVLPDTLAWPVLIAVFAVISMTLGNLAAYWQQDPRRLLGWSTVSQVGYLLVPITVAGASELALPSLLFYLGGYTVTNIAAFAVTAALPGRRDLDSYRGLARTRPWLAAALVVALLGLVGTPPTAVFIGKVTTAAAAWDGRYAWLAVVVFVNTLVSLFYYLRWIIPAFGRPHETGDADQSAVQHWPARVAVLAAALSLLLGIIAGPVWQLVT

49 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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