Description
Multidrug transporter acts as a determinant of resistance to acetic acid, flucytosine and clotrimazole, these 3 compounds acting synergistically against the pathogen (PubMed:23805133, PubMed:27148215). Reduces the intracellular accumulation of the antifungal agents flucytosine and, to a moderate extent, of clotrimazole (PubMed:23805133). Its role in acetic acid resistance may be indirect, presumably through the transport of a still unidentified physiological substrate (PubMed:23805133).
Family
Belongs to the major facilitator superfamily. CAR1 family.
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Sequence
MVESGPHSINDDLSTNEYIEQPKFYHDDHASDSNSLSDIDDDNKKHGGLYGTVSRTTTRELPEDLESEISSTHSQDAKEDLEIQHNAAPYSLLNYRDKWCMVALLTACGFWSSLGSPIYYPALKQLEKQFDIDENMVNITVVVYLLFQGLAPTCSGGLADKFGRRPVLLIGMLIYVVASIGLACAPSYGVIVFLRCVQSIGISPSIAISSGVVGDFTVKSERGTFVGATSGFVLLGQAFGSLIGAALAAAWDWRAIFWFLTIGCGASFAICFALLPETKRSIVGNLSIRPKNPLNIAPVTLLPAARRKLKYDNPDYETLDKTKPVFDLTSAFKICALPEIFLSLLPPGLAFAMWTLMLSAISSELSAAPYNYKLTIIGVCYLPAGIGGLIGSFATGKIIDFQYKKKLKVFEEKKAAGIIPEDEKFNIMGARLQSVLPQNFLCVVTYILFGWSCDKGWKIPSILITSCVSSFCAMSTLSAMSTLLVDLYPGKSSTASSCFNFMRCSLSAILMGCFAKMKHSLTVGGTFTLLAGLVFVGNFLMFIPMKHGMRWREEREQRAALKAKSMDQANENGYKLFSKIKFSSPFKSEEKV
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service