In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.

428 amino acids

MRLEIGNIFIKDIQFGEQTKVENGVLYVNKDEMIKKLSVIEHIKSVDLDIARPGESVRITPVKDVIEPRVKVEGPGGIFPGVISKVETDGSGRTHVLKGAAVVTTGKVVGFQEGIVDMSGVGAEYTPFSKTLNLVVIAEPEDGIEQHRHEEVLRMVGLNAGVYIGEAGRSVTPDEVKVYETDTIFEGAAKYPNLPKVGYVYMLQTQGLLHDTYVYGVDAKKIVPTILYPTEVMDGAILSGNCVSSCDKNPTYVHCNNPMVEELYAMHGKEINFVGVIITNENVYLADKERSSDWTAKLCKFLGLDGAIVSQEGFGNPDTDLIMNCKKIEMEGVKTVISTDEYAGRDGASQSLADADVRANAVVSNGNANMVIVLPPMDKTIGHIQYIDTIAGGFDGSLRADGSIEVEIQAITGATNELGFGYLSAKGY

46.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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