Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).

Belongs to the extended synaptotagmin family.

889 amino acids

MAQGDPGGQTPQAPQGTDKKPDEPKATEKPQGAGPQPRDPPGGEKGLRDPPGGEKGPRDPGQGGAGEALAEALYGLGRPVLRAVLYLFPVYLCGRFGLSPTWLLFGLFLWMFWTRNKKFKLARIQAAWDLHENEKLGVTRGLYLQQLPAWVNFPDVERVEWLNKVVGQMWPYIGMYVEKMFQDKVEPLVRSSSAHLKAFTFTKVHLGEKFPRINGVKSYTKNVDKREVILDLQLSYNGDVEINVEVKKMCKAGVKGVQLHGTLRVILAPLLPDLPFVGAVTMFFIQRPHLDINWTGLTNVLEIPGVSDFSDSMIVDMIASHLVLPNRFTVPLSSQVQAAQLRFPLPHGVLRLHLIEAEDLIPKDNYLKGIIRGKSDPYAVLRIGNQNFKSRTIKENLNPKWGEMYEFVVHEVPGQDLEVDLYDEDPDKDDFLGSLVIGLEGVMQDRVVDEWFPLSDVPSGSVHLRLEWLSLLPKSEKLSEAKGGISTAMLIVYLDSASALPRNHFEYSSSEYTTRKQRHMTYTKTDKDPNSYVLMSVGKKSVKSKTCTGSTEPVWGQAFAFFIQDVHMQHLHLEVKDSERQCALGMLDLPLHRLLGNEELTADQRFPLANSGPNSTIKMKIVLRVLHVEAPEPESIYTGINSLKQGPVSIKRAQSQQHKSHGKSHQAHHQAHQTQQNHTVQQPKAERKESISTTSQQANTSSSNPAPNQNPNSTGAVPESHTPSLKPLERIAPSLLSLNSIGSSVFDPNDKRWPSEMTGEVEVSVRYASLRRCLVVLINSCRNLIQCSSNGADPYVRIYLLPDRKWSGRKKTSVKRKTLNPQYNERFEFLVSQEEAKKRMLDVAVKNNRGFGSHERKELGKVLVDLSCDDLVKGFTKWFELTPTGLPTS

99.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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