Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.

Belongs to the nuclear hormone receptor family. NR3 subfamily.

673 amino acids

MASSPGLDPHPLPMLQLQEVGSSKVSERPRSPGLLPAVYSPPLGMDSHTVCIPSPYTDSSHEYNHSHGPLTFYSPSVLSYSRPPITNSPSSLCPSLSPSAFWPSHNHPTMPSLTLHCPESIVYNEPSPHAPWLESKAHSINASSSSIIGCNKSLVKRSEEGVEDMNSSLCSSAVGKADMHFCAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCSYRGARHRRGGLQPRDPTGRGLVRVGLGSRAQRHLHLEAPLTPLAPILQAKHVHLSAMSPEEFISRIMDAEPPEIYLMEDLKKPFTEASMMMSLTNLADKELVFMISWAKKIPGFVELSLADQINLLKCCWLEILMLGLMWRSVDHPGKLIFSPDFKLNREEGQCVEGIMEIFDMLLAGTSRFRELKLQREEYVCLKAMILLNSNLCTSSPQTAEELESRNKLLRLLDSVIDALVWAISKMGLTTQQQTLRLGHLTMLLSHIRHVSNKGMDHLSTMKRKNVVLVYDLLLEMLDANTSSGGSQPSSSPSSETYSDQHQYPQPPSHLHPGSEQTTADHAIVPPLGPTDDPILDGHLDAMPLQSSPPFQSLVVPHMDTNDYIHPEQWSLGTGDAAPSVEPTDYITTERVVMETALVTQP

74.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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