Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling (By similarity).

Belongs to the ELP1/IKA1 family.

1253 amino acids

MKNLVTHLHHVFPNVNGSIKALAFNSISDKIYVVCGLDNENPGIEIYEISENDDVSKLVEFDSPSFVSDNGDIDEIQSMQFLGEPMAICLSLKGGDIVMVKVDPSPEEAPWEIIGNVENGIVASCWSTDEQVFCIITGGDTILFMTKNFDIISETSLSDADLNEFNKHISVGWGRSETQFRGKRVRAKLRDPTLPEKIDEGKLSDVDDGKTYICWRGDSQYVSINRLEKGPRRAIRVYSREGLLDSISEPQDGQQSLLSWKPSGSVLATIKSDSSDNSSKVIFFERNGLRHGEFSLRRREDEKYTGLAWNVSSSILAVSTENSVMLWTTGNYHWYLKKEINIPQNALISWHPEHANTLYITGKNHIEKVVFDLKYVTEFSTSPNDFGLIPVIDGSSLLVTPLSLCNIPPPMCRYKLSLDYNVQMTSINATSDMLFAADDRRLTAFTFNSQEDIAKFGEFDISTYAEGLNFKSLLGLSGNQVLLLADGTNNCSKFFVFQCDEDNESLKLLASESFESCILNASYCSEMLFFQTSSGKLISYNLNVKSIESISLSFPKPCSDFVVVPVHETFVPIGLTSYGRLYAEQRLLSTGVLSFFCTERFVLFTTTKNLLKFVHLVSTVDDLQVVEDDAVDRHDERCRVVERGSKIVASMPSKMAVVLQMPRGNLETIYPRIMVLDGVRTYIKALKYGDAFKVCRTHRLDLNILFDYDPDLFLKNIPVFVDGLYRVDYLDLFLTSLKPENVTTGMYSDTSKSQSQQSVTTIDNKVNLLCKIIREHLTSKYGDTHFQAIITSYLCESPPKIEAALGMISGLIKAQSETVDLAIEHMCFLVDVNMLFDHALGLYDLKLALLIAQQSQKDPREYVPFLHEFQKQESLRRKFNIDCYLKRYERALGHLKEMENAFDEFKNFTIQHKLYPRALELYKYDKEAQKEVLIIFAQYLRENGKSNEAAIAYESVGKISEAIEAYKSAGMWRECLSILQQTTNSEDLIRETAEDLASLCIEKREHCDAGSINLLYLSNPREAVIQMCKGSQYSEAIRIARATGDSSIYKDLLISVLGESFGEASELVADFRNQIKSQTERILVLREKKKEDPISWMEGTMEDQTPDDISLASTSLSTNRSLYTQYTKSSNSSKMTRNTSKNNRRLERKRARGKKGTVFEEEYLVNSLRRLIARVEEIRPEVHRLLEALVRCNMTTQASELQRNFANVIGTIGEKVIPILSVPVSTFETALGEQPQAPVVPNVKPFEKLSILI

141.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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