Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level.

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily.

527 amino acids

MATQQQQQQQQQQQQQIKARKDIQIQQAQSASDILGPPEISETEITTESILGDGSFGTVYKGRCRLKDVAVKVMLKQVDQKTLTDFRKEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELMKGNLESLLLDPMVKLPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQGRLFNEKADVYSFGLVLWQIFTRQELFPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSELEEIIIDCCIPDEYGAILWKNHFKHENEANWKDFINVFSNFVGLTNANTPSMSDLLQFSPNLNGSTIELNFKCLKSIIVSSPKGPHEEEVVLMEQFGKVLAWFGNLKEDGSQILDKIRQLMECAWFHGDISTSESENRLRQKPEGTFLVRFSTSEYGAYTISKVSKNGGISHQRIHRPQGKFQVNNSKYLSVKELITGEAQALGINTPCLGSRFLSLIYKAQLSGYIN

59.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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