Converts 11-deoxycorticosterone to corticosterone and 18-hydroxycorticosterone, and also produces aldosterone. May play a role in the biosynthesis of glucocorticoids as well as mineralocorticoids. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Belongs to the cytochrome P450 family.

503 amino acids

MAIWAKAEAWLAGPWLALNRARTLGTRAVLAPKGVLPFEAIPQFPGKKWMRVLQLWREQGFENNHLEMHQTFQELGPIFRFDVGGRNMVLVMLPEDVERCQKVEGLHPQRDVPGPWLAYRHLRGHKCGVFLLNGPTWRLDRLQLNPGVLSLQAMQKFTPLVDGVARDFSQALRARVMQNARGSLTLDIKPSIFRYTIEASNLVLFGERLGLLAHQPNPESLDFIHALEVMFKSTVQLMFMPRSLSRWTSTGTWKEHFEAWDCIFQYANKAIQRLYQELTLGHPWHYSGVVAELLTHANMTVDAIKANSIDLTAGSVDTTAYPLLMTLFELARNPEVQQALRQESLAAAARISENPQKAITELPLLRAALKETLRLYPVGIFLDRCVTSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARPERYHPQRWLDNQGSGTRFPHLAFGFGMRQCLGRRLAQVEMLLLLHHVLKNFLVETLVQEDIKMIYRFIMTPSTLPLLTFRAIS

57.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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