Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).

Belongs to the peptidase C14A family.

277 amino acids

MENTENSVDSKSIKSLEPKIIHGSKSVDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMASRSGTDVDAANLRETFINLKYGVRNKNDLTREEIVELMRNVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPLDLKKITSFFRGDCCRSLTGKPKLFIIQACRGTELDCGIEADSGVEDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFYH

31.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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