ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.

825 amino acids

MNRDDPRLTYNHPYKPYDIQVQLMDAIYDTIQNKYKVGLFESPTGTGKTLSIICSSMTWLRNYKKTQDHSTMGSNSSNDNDPNQTSDSDEEPDWVKEAHIKNIRSRTSGLAIDYERHLEELSQTPHAGHTVELGQRTHKRKKRATNDDDFLPDDYNSDTDSNSVETKNAKLQQEINQIMKRVDGSDGKTPGFVNTCPVTIFFSSRTHSQLSQFAHQLSITSFESSLGEIAERIKFMPLSSRKQLCIHPKVSSLSSVSAVNDACVELQQKSDKRCEFMPRVNNPESDQLVQRFADYSFAVIKDIEELHELGADLKVCPYYASRRNIENSEIIALPYQMLLQQATRKSLGLSIKDSIVIIDEAHNLLDVISSINSVSITRKELSSVIASLKLYYNKFTKRLNSGNRIHLMKLIKLCSLVETYIKNCEIQNKCVPGSDVLIDELFQGSTGDLLNIHRIEKYLDKSKIAYKIQTYIEQSREESDEKQASSPLLFKVTAFLKSLVNPSKEGRFFWDKINDDTEIKYLLLDPSEMFRDVVESARCVLLCGGTMEPVEDYYRYLFPYVPGEKIKKFTCGHIVPQENIEVLTVSSRKTTVFDFSYHKRNDPSMLRELALSLQDICERVPNGIIVFAPSYKYLNQLISTWRKDGNLAKISTLKQVFLESSDSTSIESILRDYGAAARGSGAILFSVVGGKMSEGVNFSDELARAVIMLGLPYPNAFSGELIAKRKFIEETTLSKGGTQAMAKKNSREYYENICMRAVNQSVGRSIRHANDYSVIVLFDTRYNSSHIQSKLSGWMRSSIRPERESFDMTLERIADFFAAKTLTKR

93.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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