zic2-b

Zinc finger protein ZIC 2-B

497 amino acids

Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation. Regulates anteroposterior patterning in early development by inhibiting expression of the nodal genes through the inhibition of vegt. Required for gastrulation movements and for proper anterior neural and axial development. May also act as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).

Belongs to the GLI C2H2-type zinc-finger protein family.

53.489 kDa

MLLDAGPQFPALGVGTFARHHHHHHHHHAAVAAAAAAAAEMQERELSLAQNSFVEPTHMGAFKMNPGGGSGGGSGGGGGAGPNGGAGASGPHDLSPPGQTSAFTSQAGYPASALAPHSAYTGAAAFNSPRDFLFRGRGFAEGSAAAGGGQHGLFGPPAGSLHHHPHHHHQLSHGEHPQGHLLFPGIHDQHAAASQNTLGGQMRLGLPGEVFGRTDQYRQVSSPRGDPYTAAQLHNQYSPMNMGMNMAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLNNPKKSCNKTFSTMHELVTHMSVEHVGGPEQSNHICFWEECAREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPNSETQNPNLSPAAVSAVHSVSSGASGTLASNFNEWYV