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ypjF

Gene
ypjF
Protein
Toxin YpjF
Organism
Escherichia coli (strain K12)
Length
109 amino acids
Function
Toxic component of a type IV toxin-antitoxin (TA) system (PubMed:14594833, PubMed:28257056, PubMed:28931012). Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB (PubMed:28931012). Overexpression results in inhibition of growth in liquid cultures (PubMed:14594833, PubMed:28257056, PubMed:28931012). Overexpression leads to formation of lemon-shaped cells; inactivated by overexpression of cognate antitoxin YfjZ but not when the 2 genes are coexpressed from the same plasmid (PubMed:28257056). Also neutralized by overexpression of non-cognate antitoxins YafW and CbeA (PubMed:28257056).
Similarity
Belongs to the CbtA/YkfI/YpjF toxin family.
Mass
12.308 kDa
Sequence
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGFSWQQQSPYISVVDILRARRSTGLLKTNVK