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yopT1

Gene
yopT1
Protein
Cysteine protease yopT1
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Length
322 amino acids
Function
Cysteine protease, which is translocated into infected cells and plays a central role in pathogenesis by cleaving the C-terminus end of the human small GTPase RhoA/ARHA, a regulator of cytoskeleton. Once cleaved, ARHA loses its lipid modification, and is released from the cell membrane, leading to the subsequent disruption of actin cytoskeleton of the host cell (By similarity).
Similarity
Belongs to the peptidase C58 family.
Mass
36.082 kDa
Sequence
MDSIHGHYHIQLSNYSAGENLQSATPPEGVIGAHRVKVETALSHSNRQKKLSATIKHNQSSRSMLDRKLTSDGKVNQRSSFTFSMIMYRMIHFVLSTRVPAVRESVANYGGNINFKFAQTKGAFLHQIIKHSDTARGACEALCAHWIRSHAQGQSLFDQLYVGGRKGKFQIDTLYSIKQLQIDGCKADVDQDEVTLDWLKKNGISERMIERHCLLPTVDVTGTTGSEGPDQLLNAILDTNGIGYGYKKISLSGQMSGHTIAAYVNENSGVTFFDPNFGEFHFSDKEKFSKWFTNSFWENSMYHYPLGVGQSFSVFTFDSKEV

Gene
yopT1
Protein
Cysteine protease yopT1
Organism
Yersinia enterocolitica
Length
322 amino acids
Function
Cysteine protease, which is translocated into infected cells and plays a central role in pathogenesis by cleaving the C-terminus end of the human small GTPase RhoA/ARHA, a regulator of cytoskeleton. Once cleaved, ARHA loses its lipid modification, and is released from the cell membrane, leading to the subsequent disruption of actin cytoskeleton of the host cell.
Similarity
Belongs to the peptidase C58 family.
Mass
36.201 kDa
Sequence
MDSIHGHYHIQLSNYSAGENLQSATLTEGVIGAHRVKVETALSHSNRQKKLSATIKHNQSSRSMLDRKLTSDGKVNQRSSFTFSMIMYRMIHFVLSTRVPAVRESVANYGGNINFKFAQTKGAFLHQIIKHSDTARGACEALCAHWIRSHAQGQSLFDQLYVGGRKGKFQIDTLYSIKQLQIDGCKADVDQDEVTLDWLKKNGISERMIERHCLLPTVDVTGTTGSEGPDQLLNAILDTHGIGYGYKKIYLSGQMSGHTIAAYVNENSGVTFFDPNFGEFHFSDKEQFSKWFTNSFWENSMYHYPLGVGQSFSVFTFDSKEV