Protein
Exodeoxyribonuclease III
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function
Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities (By similarity).
Similarity
Belongs to the DNA repair enzymes AP/ExoA family.
Sequence
MKFVSFNINGLRARPHQLEAIVEKHQPDVIGLQETKVHDEMFPLEEVAKLGYNVFYHGQKGHYGVALLTKATPISVRRGFPDDGEEAQRRIIMAEIPSPLGNITVINGYFPQGESRDHPLKFPAKAQFYQNLQNYLETELKCDNPVLIMGDMNISPTDLDIGIGEENRKRWLRTGKCSFLPEEREWMSRLLKWGLVDTFRQANPQTMDKFSWFDYRSKGFVDNRGLRIDLLLASAPLAERCAETGIDYDIRSMEKPSDHAPVWATFRV