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xanD

Gene
xanD
Protein
Xanthocillin biosynthesis cluster protein D
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
156 amino acids
Function
Part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives (PubMed:29844112). The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB (PubMed:29844112). Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB (PubMed:29844112). Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces N-formyl groups and the methyltransferase xanE which introduces methyl groups, leading to the production of several derivatives including fumiformamide (PubMed:29844112). Finally, fumiformamide can be subject to both oxidative and reductive cyclization to yield melanocins E and F, respectively (PubMed:29844112).
Mass
17.17 kDa
Sequence
MQAILETVSNLLPYHLLSYGALLGTELFQSFVNTKICYQALPMKEFLALQKRVFPAYFRCQVGLVVLTAVTRPPYSILSFSQHIWDSVPLIAVGVTGALNCAMNEDNSSTTDPAKIQQANKTFSRNHAMSIHLNAIALVATVWYGFTLSSSLLNGL