xan1

Gene

xan1

Protein

Alpha-ketoglutarate-dependent xanthine dioxygenase xan1

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

413 amino acids

Function

Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid (PubMed:15948966). Allows xanthine utilization as a nitrogen source (PubMed:15948966).

Similarity

Belongs to the TfdA dioxygenase family.

Mass

46.604 kDa

Sequence

MSATATTTVVEPPTTTLTGATEPPFTAYTTSQGLRVSPVPLPEHNTDVGFGALIENVDLNNLSDEQFEDIRKALFEHQVVCFPNQHNLPPETQYAITHRFDPESSTYGHGNRTNQQNNSILHPDLHTLPGVPQVQLIGHGVVKDHYGLEEVRLKHPHHRTFHRDPISEEEEKEKQVTRFYRWHIDAALYDYNPPVVTTLLAVNAPQGTQTLRYDDKSGHEMPVPLGSTAFASGYRMYELLTDEEKKVAARTRVQYFPHAYVTINKARALPNGLGMYSEGLELDKSELPPWEESRVKTFPLLWKNPVTGKLALQTHGCCAEKILIDNEDGTTTVIDDLPKVREILYNYQRPGINPERVYCHDWKNGDFVIFHNRGVTHCITGAYRDDQTRIFHQCNLAASHPPAGPSEEDIAAM

Protein

Alpha-ketoglutarate-dependent xanthine dioxygenase xan1: xan1