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xan-1

Gene
xan-1
Protein
Alpha-ketoglutarate-dependent xanthine dioxygenase xan-1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
420 amino acids
Function
Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid (PubMed:15948966). Allows xanthine utilization as a nitrogen source (PubMed:15948966).
Similarity
Belongs to the TfdA dioxygenase family.
Mass
46.41 kDa
Sequence
MASNTTVPVITPLAHPEGSKLDFGATVSGVDIENLTDRDFAILRTALFTHQVLVIKSQSHVSPRAQYELTQRFDPLAAPLYGHGNTDSGSVGSKSILHPDLKTIPHQPQVQVIGNGFVPTYEGLSNIQLRHPHHRTFHSTSIPASHDLTHTRFYRWHIDAALYGGVARAPPVVTTLLAVKVPQGRRQTCVYDDGTGDELDVPLGTTAFVSGYKMYDILSETQKAFARSTRVEYAPHPYVWMSSAKSRSTGLGLVSEGKEMPMEELPEIEEDRIQILPMCWRNPVTGKLALQVHPSAVRRLHLEDGTVVEDLKEVREIVYGLQRPGIAPGLVYAHDWEEGDLVIFHNRGTLHSVVGAFAESEVRLFRQCNIAGSEFPMGPEEEEKEEELVHAEQEEGVVEVTKQESLPELRMGAVEVGVAA