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wt1-b

Gene
wt1-b
Protein
Wilms tumor protein homolog B
Organism
Xenopus laevis
Length
407 amino acids
Function
Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule-specific gene expression in the portion of the pronephros fated to form the glomus (PubMed:16818449). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Inhibits Wnt-signaling during embryonic development (By similarity).
Similarity
Belongs to the EGR C2H2-type zinc-finger protein family.
Mass
45.983 kDa
Sequence
MGSDVRDMNLLPPVSSLSGNSSCNMPVSNSSQWAPVLDFPPGAPYSSLTPHSFIKQEPTWNPDPHEDQCLSAFTVHFSGQFTGTAGACRYGPFGAPTPSQATTGQARMFPNAPYLSNCLDNQQSMRNQGYSAVAFDGTPSYGHTPSHHTAQFTNHSFKHEDPISQQTSLGEQQYSVPPPVYGCHTPTDTCTGSQALLLRTPYNSDNLYQMECMTWNQMNLGSSLKSHGTTYENDSHSAPMLYSCGGQYRIHTHGVFRGIQDVRRVPGVTPAIVRSTEANEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL