wrnip1

ATPase WRNIP1

876 amino acids

Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity).

Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

98.566 kDa

MSKKTNINTNTKINNFFQTKTNNANVVNEKGYIEDDNEIIDINDFEEDQNLYKIQNKSNGNNSINNNNNNKNTPTKPNLNLTPTKSHTISFPTRPKLPSFTQPNNNNNNNNNNNNNNNINNNNNNNNNNNNNNNNNNNNNNNNSSTNVKPTTTTTTTTTINNNNNNNNNNNINNNNIDLKNKYSFLTNFKKKSFAPLSEQMRPTELSDFIGQESLLVGDPIVKKLFQSPELPSFILYGPPGCGKTTLAQIVASKSNYNINALSAVGSGVKDIKEVIDKARNTLQFGKKTILFIDEIHRYNKLQQDVLLPAIESGIIILIGATTENPSFELNGALLSRCKVFKMEKLTKENLETLIKRTLEVTPLLMDRRLIMDEDAIKSLAEIADGDARVAINVLDMAIKANKEEQTYKERMEEKHSTSGIVRDIVLTKKQMGSLLQRTSLIYDKGGDAFYELISALHKSVRGSDANATAYWVIRMLESGCEPLYIVRRMVRMASEDIGLADNSALPLAIAAYQAVHFVGMPECTNAILQCAVYLANAAKSNSCDHWYAHTREYLEKHEGPPVPIHLRNAPTKMMKDWGYGADYQYNHAFDDQSQVTQIYLPEPIKNEKFFEYKLTCPSVKDRQQSQDQTQRSSQQQQQQQTQPQQQTQPQQQTQQQIQQQLEQLKQIQQQLEQQVQQQIQQQSSQSPSQQSQLQELQQIQQQLQQIQQTNSQINNKNNDSNIIKKNVNNSLDLNPTLPKKQKMIIPSILDNSNNNNNNNNINKSPTPIKKANISHNQLDSSINTSAITIDDSSECDINFDDDFDMASVSSTTMISNIPVGANVAGATEAETETKAISSTDTKESVSINDSDKDLTTTHKNEQDQNNPPDPISLDF

WRNIP1

ATPase WRNIP1

665 amino acids

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.

Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

72.133 kDa

MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEPAMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC

Wrnip1

ATPase WRNIP1

660 amino acids

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.

Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

71.794 kDa

MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPARKGMGKRPAAAAAAGSASPRSWDEAEAQEEEEAGVDGDGDADVDGEDDPGHWDADAADASFGVSAGRAHPRALAAEEIRQMLEGKPLADKMRPDTLQDYIGQSRAVGQETLLRSLLEANEIPSLILWGPPGCGKTTLAHIIANNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNCSSEPSVFIEDKAVDTLAYLSDGDARTGLNGLQLAVLARLSSRKVFCKKSGQTYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKAMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALAQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRSHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQDYLPEELRGVDFFKQRRC

Wrnip1

ATPase WRNIP1

660 amino acids

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.

Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

71.934 kDa

MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGPHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPARKGLGKRPAAAAAAGSASPRSWDETEAQEEEEAGVDGDGDADVDGEDDPGHWDADAADASFGVSAGRAHPRALPAEEIRQMLEGKPLADKMRPDTLQDYIGQSRAVGQETLLRSLLETNEIPSLILWGPPGCGKTTLAHIIANNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNTALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNCSSEPSVFIEDKAVDTLAYLSDGDARTGLNGLQLAVLARLSSRKMFCKKSGQTYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKAMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALAQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRSHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQDYLPEELRGVDFFKQRRC