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wnt11b-2

Gene
wnt11b-2
Protein
Protein Wnt-11b-2
Organism
Xenopus tropicalis
Length
353 amino acids
Function
Ligand for the frizzled7 transmembrane receptor. Primarily acts via non-canonical Wnt pathways mediated by either Ca(2+) and PKC, or by JNK and dvl2/dsh. Depending on the cellular context, can also signal via the canonical Wnt pathway mediated by beta-catenin and dvl2/dsh. May also inhibit canonical Wnt signaling. Maternally initiates dorsal/ventral axis formation by a canonical route, which signals via lrp6. In a complex with wnt5a, activates the canonical and non-canonical processes involved in axis formation. In the non-canonical pathway, acts through fzd7/fz7 to induce phosphorylation of dvl2/dsh. Signals through a non-canonical Wnt pathway to regulate convergent extension movements during gastrulation. Interactions with the secreted Wnt antagonist sfrp5 to coordinate foregut development, acting via a non-canonical wnt pathway whereby sfrp5 restricts wnt11b activity to prevent inappropriate foregut formation. Mediates cardiogenesis via non-canonical Wnt signaling involving JNK-activation and PKC. Acts redundantly with wnt11/wnt11r during pronephros induction (By similarity).
Similarity
Belongs to the Wnt family.
Mass
38.858 kDa
Sequence
MALIRHCVTLLLILCCSRLCGAIQWLGLTVNGSRVAWNESEHCRLLDGLVPEQSQLCKRNLELMQSVVNAAKQAKLTCQMTFSDMRWNCSSVENAPNFTPDLSKGTRESAFVYALASATISHTIARACASGELPTCSCGATPAEVPGTGFRWGGCGDNLHYGLNMGSAFVDAPMKSSKSGGTQATKMINLHNNAVGRQVLMDSLETKCKCHGVSGSCSVKTCWKGLQDLPHIANELKSKYLGATKVIHRQTGTRRQLVPRELDIRPVRESELVYLVSSPDYCAKNPKLGSYGTQDRVCNKTSVGSDSCNLMCCGRGYNAYTETIVERCQCKYYWCCYVMCKKCERTVERYVCK