Protein
Wee1-like protein kinase 2-A
Function
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', which inhibits cdk1 activity and prevents meiotic reentry. Negative regulator of mitosis. Involved in the mitotic DNA replication checkpoint.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Sequence
MRTAMSCGGGLVQRLDFSSSDEEDGLSNGINEGPQKGSPVSSWRTNNCPFPITPQRNERELSPTQELSPSSDYSPDPSVGAECPGTPLHYSTWKKLKLCDTPYTPKSLLYKTLPSPGSRVHCRGQRLLRFVAGTGAELDDPSLVNINPFTPESYRQTHFQPNGKRKERPEDDCRTDRQMKYAEKEHPAVFQSKRFVLRETNMGSRYKTEFLEIEKIGAGEFGSVFKCIKRLDGCFYAIKRSKKPLAGSTDEQLALREVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCNGGSLQDLIVDNNKEGQFVLEQELKEILLQVSMGLKYIHGSGLVHMDIKPSNIFICRKQTELGQEESDGEDDLSSGSVLYKIGDLGHVTSILNPQVEEGDSRFLANEILQEDYSQLPKADIFALGLTIALAAGAAPLPCNEDSWHHIRKGNLPHVPQLLTPIFLALLKLLVHPDPVMRPPAASLAKNSVLRRCVGKAAQLQKQLNVEKFKTAMLERELKAAKLAQTSGKDECSDLPPMSGFSCRGRKRLVGAKNTRSLSFTCGGY