Protein
Wee1-like protein kinase 1-A
Function
Acts as a zygotic negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed cdk1 before the onset of mitosis by mediating phosphorylation of cdk1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed cdk1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-cdk1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric cdk1 does not occur. Involved in convergent extension of the paraxial mesoderm during neurulation by inhibiting the cell cycle.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Sequence
MSLQPVPHRLLFSDSDDEEDGHSTGEDSAFQESDSPVSRLREKQEGPGGSWEEEEGLGSSPIKSPGHFFMCDSPTYRDLPPASPPGPAASPPDCPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIGSSALRFRGGTLFREAEKLPKPEFTYSTPQVNINPFTPDSLEIQSSTGLCRRRKRALLNDSCGEDMEGSDCELEDEDVRPAKRIPITESNMKSRYATEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPMAGSVDEQNALREVYAHAVLGQHPHVVRYYSAWAEDDHMLIQNEYCNGGSLADAISENYRTMQYFTEPELKDLLLQVARGLKYIHSMSLVHMDIKPSNIFISRITVPNTGVEEGDDEDCGSGNVVYKIGDLGHVTRVSSPQVEEGDSRFLANEVLQEDYTHLAKADIFALALTVWCAAGAEPFPTNGDQWHEIRQGKLPRVPQLLSQEFVDLIKLMISPDSEKRPSSMALVKHSVLLSASRKNAEQLRIELNAEKFKNALLQKELKKAQIAKAAAEERALFPDRIATRSTTQSNRTTRLIGKKMNRSVSLTIY