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wapl

Gene
wapl
Protein
Protein wings apart-like
Organism
Drosophila melanogaster
Length
1741 amino acids
Function
Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation.
Similarity
Belongs to the WAPL family.
Mass
185.156 kDa
Sequence
MSRWGKNIVVPLDSLCKEKENTNRPTVARSVGTVGKWGKMGFTSTRTYTLPAIHPMAAAAAAAAAAASPSQSPASTQDHDPNDLSVSVPEPPKPKKFFKSRNTAPPEVIAQIIQQLPHCGAGASPMRDHFSSAGAGAGGLTPTSGAQEAGGVKLKPGKGASSAERKRKSPKKKAATTSASTPSTPGAFYGASDRDGDGLSDPASEQPEQPSSASGKQKQKKPKEEKKLKPEAPPSRVLGRARKAVNYREVDEDERYPTPTKDLIIPKAGRQPAEVAATATLAAASSEAFISSTFGSPGSEPSLPPPTSAPSASASTSSQLPSASGSASNPPSASRTPEHPPIVLRISKGTSRLVSTDSEEPPSSSPAHQNQLNQLSVTEEEPAERSGDETVPASTPKITVKPLRPPTAADSVDGSSAAVGGASAGDSFEERKSQSLEPNEDEEEEEEEEDEEEEPPEINYCTVKISPDKPPKERLKLIIKTDVIRNAIAKAAAAAESRSEKKSRSKKHKHKQLLAAGSGAAPASGATPAEINSEFKTPSPHLALSEANSQQAQHTPSHLHQLHQLHPQRGSAVISPTTRSDHDFDSQSSVLGSISSKGNSTPQLLAQAVQEDSCVIRSRGSSVITSDLETSQHSSLVAPPSDIESRLESMMMTIDGAGTGAASAVPETPLQEDILAVLRGEVPRLNGNTDPEPTEEEDQQQQPKRATRGRGRKANNNVDVTPPATETRTRGRAKGADATTAAISPPTGKRNTRGTRGSRKAEQEVDMEVDETAMTTVPANEEQLEQATLPPRRGRNAAARANNNNLASVNNNINKIAANLSAKAEASRLAEGGVAGGAARSYGRKRKNQQVTQVLQQEPVPEEQETPDAEEEQPTPAKIPHTDHREHSPDHDPDPDPDELSNNSNNSSLQHDGSSSSPPPRDFKFKDKFKRTLTLDTQGAANAGAGGAAAAAPPESSGEQRGAVKLVISKKKGSIFKSRALVPSDQAEQATVAKRHLYKHSWDAALEANGGGTNSDASNASASGVGVAGAKDHLHHLAAGKSDGDFGDSPSSNNNGSSSACSSASTLRGDSPALGKISRLAGKQGVPATSTSSDAFDLDLEPIAGELDLERSAAGASAGGTGATTGGGGATGGGGPVRVDRKTKDYYPVVRNVKTAHQIQEIGEYQEMDDDVEYILDALQPHNPPATRCLSALQLAAKCMMPAFRMHVRAHGVVTKFFKALSDANKDLSLGLCTSAIMYILSQEGLNMDLDRDSLELMINLLEADGVGGSTETGHPDRAGYDRNKQKVRELCEEIKAQGKGTHLNVDSLTVGTLAMETLLSLTSKRAGEWFKEDLRKLGGLEHIIKTISDFCRPVIACDTEIDWQPTLLDNMQTVARCLRVLENVTQHNETNQRYMLTSGQGKAVETLCQLYRLCSRQIMLHPSDGGGSNKEHPGVAMRELLVPVLKVLINLTHTFNEAQPSLGAELLGQRGDVVETSFRLLLLSANYIPDQCVFELSILVLTLLINLCMHTVPNRAALMQAAAPAEYVADNPPAQGSVSALQALLEYFYKCEELARLVEKNTDAFLESNEKGKKKQEEVEETVNNLVQRAGHHMEHTLKGSYAAILVGNLIADNELYESVVRRQLRGNSFKEIIGVLEKYHTFMNLTSSLEAAFVAHMKSTKRIIDNFKKRDYIYEHSDEHDNPLPLNLETTAQVLAVGADASHAATSSTTVGSGSAPSSTSATGTTRAPRVYKTYSSHR

Gene
Wapl
Protein
Wings apart-like protein homolog
Organism
Mus musculus
Length
1200 amino acids
Function
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).
Similarity
Belongs to the WAPL family.
Mass
134.07 kDa
Sequence
MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEEDTGDPFGFDSDDESLPVSSKNLAQGKGSSYSESSEAAQLEEVTSVFEANSKCSHVVGEDSFASDRCLLVEDTLIGKEKSISRIPEDNANKSSCTKLLTSDKVENFSEEHEKNSHHFHKNAEDSTKKPNAETAVASEYKADETKETNDTWNSQSGKRTESPSESCPVKGSVRTGLYEWDNDFEDIRSEDCILSLDNESLLEMKDEDLKNRIGGLENLNETFEEDIIQSVLRPSNCRTYCRANKARSSQGASNFDKLMDGTSQSLAKANSESSKDGLNQAKKGSASCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHDETGGDEGGSGSSNYKIKYFGFDDLSESEDDDDDDCQVERKKDKKRTKTAPSPSQQPPPESSDNSQDSQSSTNNAENLDFTEDLPGVPESVKKPISKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSEELPGPPIAKPQRVTVRLSSKEPNQKDDGVFKAPAPPLKVIKTVTIPTQPYQEIVTALKCRKEDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDDEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIISSAKALQHCEDLIQQYNRAENSICVADSNPLPYQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQEGLIGTAMNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMQTSCSFDSSFSSGEGDHSLRLAGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGAEEKQKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC

Gene
WAPL
Protein
Wings apart-like protein homolog
Organism
Homo sapiens
Length
1190 amino acids
Function
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Similarity
Belongs to the WAPL family.
Mass
132.946 kDa
Sequence
MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSESSEAAQLEEVTSVLEANSKISHVVVEDTVVSDKCFPLEDTLLGKEKSTNRIVEDDASISSCNKLITSDKVENFHEEHEKNSHHIHKNADDSTKKPNAETTVASEIKETNDTWNSQFGKRPESPSEISPIKGSVRTGLFEWDNDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLENLNEAIEEDIVQSVLRPTNCRTYCRANKTKSSQGASNFDKLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHETGGDEGGSGSSNYKIKYFGFDDLSESEDDEDDDCQVERKTSKKRTKTAPSPSLQPPPESNDNSQDSQSGTNNAENLDFTEDLPGVPESVKKPINKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSEELPGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTALKCRREDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGTEEKHKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC