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vrk-1

Gene
vrk-1
Protein
Serine/threonine-protein kinase VRK1
Organism
Caenorhabditis elegans
Length
610 amino acids
Function
Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage.
Similarity
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Mass
67.355 kDa
Sequence
MPPKKAPAKKLHELAAEVRVGHKINDISKKTFIVGKQFATGGFGRIHTCTEEGKSQQMVMKIEPSTNGPLLTEVVVFNRILKKELIESYKKKKKISWIGLPYLIANGYFTYESEKMRYMIIPKYATSLEAVRETNGGTLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDKPDKKRAHNGTCIFTSTDAHRGNNPSFRGDIEILAYNLMMWATGTLPWMALESSPEKVFDAKQKFIAGLPGTLQNVLKNESSAVVGCIASMFDISMKTNYTDKVDMGKLKKLVTDAIQKTSSDGKKTPTRQKKLAEEDKNAVTPKRSTRRLAVKEESDNKDNDEVEVKPEKKATPRKRTTRKAVEVNNDSDDNEEQYENPKSKSSRTQTKSKRAKEEDVDDEEEIIIPKSSRSRSKVQLSGEGSDVTTPSSAASTSRSRSIRLGLTSSTASSNKVAKKIEQKYKRLSMNKSSLVPVTISVASDKSPTTSTPSSSSGLRSKRKSSEDVGEGITLKTQVLITPAIKKAKTKSGISSATKASPTELRRVPGVRNFPKGRRSMIIKETSAKYKERLASRQTKPTFDDSSCSSEV

Gene
vrk-1
Protein
Serine/threonine-protein kinase VRK1
Organism
Caenorhabditis briggsae
Length
559 amino acids
Function
Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage (By similarity).
Similarity
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Mass
62.09 kDa
Sequence
MPPKKAAPKKLHELAPEVRVGLKIDDISKKTYIVGKQFATGGFGRIHTCTEDGKSQQMVMKIEPSTNGPLLTEVVVFNRILKKDMIENYKKAKKIQWIGLPHLIANGYFTYNNEKMRYMIIPKYATSLEAVREANGGSLSAKDSLTVADCVLGALEYLHDSDYAHADVKAANILLEKPNDFSSAVLVDFGLAHRTTNNVDKPDKKRAHNGTCIFTSTDAHRGNNPSFRGDVEILAYNLIMWISGSLPWLSLEASPDKVFEAKQKFVGGLPGTLQSILTNQPAPVAGCITTMFDVSRKTDYTHKVDMAKLRKKVTEAAQSASTGAQKKPKMTPSRDTTATPKRKSQRAPRVESEDEEEEEKKEVEIKPKKKVQRSRKVVEDDDEEEEVIIPKSTRSRKTKEEGTPRSFNLGMTSSTATSDRVAKKIEMKYKRLATNKPSLVPVTVADASSCESQYESNEPGPSSRVVKKRTSEERDANGEVQLKTPALVSPDVKKTKYKSGISSATKASPTELRRVPGVRNFPKGRRSMIIKETSARYQEKRATRNTKPTFDDSSCSSEV