Function
Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Promotes expression of beta-lactam and glycopeptide resistance. Acts as a transcriptional activator of the genes among others encoding beta-lactam-inducible penicillin-binding protein 2 (pbp2), UDP-N-acetylglucosamine enolpyruvyl transferase (murZ), monofunctional glycosyltransferase (mgt), methicillin resistance-related protein (fmtA) and teicoplanin resistance-related proteins (tcaA/tcaB). Also, up-regulates genes encoding stress response proteins, such as osmoprotectant transporters proP and opuD.