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vps38

Gene
vps38
Protein
Vacuolar protein sorting-associated protein 38
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
474 amino acids
Function
Involved in endosome-to-Golgi retrograde transport as part of the vps34 PI3-kinase complex II. Mediates the interaction between atg6 and the pik3-ppk19 core complex, leading to the recruitment of atg6 to the membrane (By similarity).
Mass
55.498 kDa
Sequence
MSLELPGNYRLSRLKSIQIRNVQEIQNHSKFAINTTENLWKRDVQLKRAISEGTIRIFISLHVQSKKLPVYITETSGNANHIFYVDEKVTEKLQKYRHEEYFIVRTWCSSSSHAFKLHKEWKILRYDSNFRYIGNDPVFAVCHIRNGLLCEFNDGVYIYTTSQSSDIMRQTSFPKSASTYSIDRRKDGYTIQKITRILKLAECIDEMHIAKHEIRAHFQEEEFQQIRLMHKRMLLRDEKIDELAKLEHLWQKQINSITQMRTKFDKTKSWLSSKRNTLNKSKESLQKDEAEYVELANSLKTKVETNIEIRILMAHAIRMHVSHLSKIYPIQPSPGNHDEFTIRNLRLSFEPDKINNVEMAASIGFLAHLLQTLSKYLEKELAYPILCASSRSSILDTLTPDIPTRIFPLYPATRPIELFEHAIYLLNQDVNDFLETFGLPIDQSMDILRNFKKLLQFILSGQHLSFVQVTSTAP

Gene
VPS38
Protein
Vacuolar protein sorting-associated protein 38
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
439 amino acids
Function
Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane.
Mass
50.86 kDa
Sequence
MKRFLLSRRQRHLRMICFHNISLFRANGDSKLIKEYGDGFIPCFFILESIRGELLYVSEVQSGSLRKLSFQELPKLTGASTMIVLKLVGLVPSDILCTISSDKNGIIDDKWCVLCTYTIDLNKLQPINEDTVLITGTNAPVLDLIDGSYTLAAEKIKPLKGLVSSHKRNISQVKIKFSLAYSSLLKLNKLLEYSSQVHEEINEISSKIEDDFLSLKNQNHWYMRTVQKSIETLEKEVLQRKKSKKNIEMAQLESNDTINHSKTELSLMSQDESINDDYGSIYSRFVQIKDRLDQLRFKKLYQLIGIFHSTDLFNSDRGYIYFEKPSSVNDVINRLKLKPLNIEILLRQAGESTKHREYVNSQLGYYLLFLHLTAIQIFKAPLPYRLMYYGSTSVIDSQYPLYFTDQMISKHQAKLIKAIHYFNADILQFKQILENYRPT