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vps26a-b

Gene
vps26a-b
Protein
Vacuolar protein sorting-associated protein 26A-B
Organism
Xenopus laevis
Length
326 amino acids
Function
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).
Similarity
Belongs to the VPS26 family.
Mass
38.018 kDa
Sequence
MSFLSGLFGPICEIEVALNDSDTRKVSEIKTEEGKVEKHFLFYDGESVAGKVNIVFKQPGKRLEHHGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYNGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLASYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETVAKYEIMDGAPVKGESIPIRLFIAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKIRKRTNFHQRFEPQEPQASAEEPEI