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vps-39

Gene
vps-39
Protein
Vacuolar protein sorting-associated protein 39 homolog
Organism
Caenorhabditis elegans
Length
926 amino acids
Function
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:24374177). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (By similarity). Required for fusion of endosomes (By similarity). In association with lgg-2 mediates the tethering of autophagosomes with lysosomes to form autolysosomes (PubMed:25126728, PubMed:24374177). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423).
Similarity
Belongs to the VAM6/VPS39 family.
Mass
105.256 kDa
Sequence
MYDAYTPCEVALRLPVEVTCLAFQESNQTLLAGGRAGHLYAYTISANRRGFELTNICKSFHKKAVMELKVCQREDLLLCVSDGQLMAHKLSDPEYKVETLIHKVKPVQTFARFSPKTSGDLYVIVSSRKKLYLFKWGEKDGHKEFIEVALDYNPVFLDTPTSIRCVGEMVFFSVRNEYFSMTMQKDKTTTSPSEGSTPEGWNGFVTRLLNFNCQPGIVPMIDRRRVAFVRNEIVVTTDIWGQRPANVLSDEYKFSEVPMQIVYDSPYLVGMLSKGRVEVRSIFDGQLVQTMSLPKAMTLCSGARGQVFVAALSDIWILDTSQNLRKNVSHLIQERHFELAIQLAENSNLFAEEQKLEIKKKAALNLFNQKKFDESFALFGEIKTDISEVLSIIRMFPELLPDGFQSMTGVVSDMPANDRMRALLALGSYLSEIRTEHAKHIELYNRLYSSGAAKKTDEDEKAKLLLTLRVVDTTLLKCYIKTKPMLVDSLIRLQSNACTFEDAKKILESEGRLRSLFILYETRKKHEMALDLFIDQSSRPDADPFFDDAIQQIVEYLQSLGNSNLPLILKYAKWVLAKNLEAGVQIFTSDETEMARNLNRKAVVEFLKSECPDALIPYLEHVIFKWEEPSSYFHETLLEFYVARVNTLFKDYVHAFPDAFSDENITRAGDEDGELGLYRKRLLKFLEVSHSYSPQTVLLQLAPHAFYEERALILGRLKQHEQALAIYVNTLKNVPAAEEYCRLYYNAHDETNSQVYLMLFRTLVHPNQQQLHSIPYHADSTPFGSYRDDVSEASTLVNSTSSYQPDVNTAIKILAKHADKIDTVGALNMLPATTPLRVVFSAINAVIQTTGRQASTRKMEKSVSQCAMSKKLERKNKAQSTKIIVNFSSECVVCEKKIAVSAFVRYPDGRLAHLYCHNDSQGGNRN