vpr2

Damage-control phosphatase ARMT1

488 amino acids

Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity).

Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.

55.337 kDa

MWSPLILPLLAQIFACAFGDAVNEGCNVDPKGIHGLWYLDEPFGVYLSAIYNGSLAYIMMKERVPAIVTTVINSLEQDNDEIVQKYGVESQEELHRIVDSLKSLKTELSTNQPLTNLPLAHDEADRDAAVWNEHLDRQREIEGPNLSYFFTRFLLAESYTFRKMAHAFALAKNVRNFDFFGKQKEHLLTNSAKSLPILAHRALLEANRSKATKDEMREELAKFLKLSLWGNRFDLAASSGHEITQAGDPIELLSSFDEDLLIDHTRVAWDILNKPHGPNDPVIVDIVLDNAGYELFNDLCLATFLVSRGLATKVRFHAKQIPWYVSDVNIHDFHWVIGYMRSSSDPHLKEFGDLCARQLESGSWSVEADAFWTTFHGYGEMKKQAPVLYNTLSEATLLIFKGDLNYRKLLGDLNWEHTTSLDTALFHLDFKPTNVLSLRTIKARRVRRSYARDAASCGRRTRRRWATGRTGVIVASAKNAQCACAKSR