Protein
Variable large protein 5
Function
The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.
Similarity
Belongs to the variable large protein (Vlp) family. Gamma subfamily.
Sequence
MRKRISAIIMTLFMVLVSCNSGGVAEDPQSKFLKSAIDLGNDFLNVFTSFGDIVSKVLGFSTETKKSDVGAYFKTIQDTIQGTKDKLNKIVTDMKREGNPNASATETAVKTLIDNTLDKIIEGSKTVSDAIGDASDPIANVGANNAAGVAGTGIESLTKGIKAIVDVVLGKEGNAEAGTDKKAEDLSARTAAGNGEAGKLFAANAGDDANAKKVAADAAKAVGAVTGADILQAMVKNGANAAADAAKANAKDGTIAGAIALTVMAKGGKFAGPTADSADYVTVAKGAAVSAITKALDTLTIAIRKTIDAGLKTVKEAMKINANDTPISPEQNTPKATTNN