Protein
Valienol-1-phosphate guanylyltransferase
Organism
Streptomyces hygroscopicus subsp. limoneus
Function
Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16725283). Catalyzes the conversion of valienol 1-phosphate to GDP-valienol and less effectively to ADP-valienol or other NDP derivatives (PubMed:21766819).
Similarity
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Sequence
MDGVRAVLLAGGEGRRMGPLGRGRLKPLVPFGGTSRLIDFSIANVHRSGLRDVLLLSQYEERRLMDDLHLVWNGRHRGFRIDFGPYDAVYRRSPGKLPEQLPERIWPLERGTADALLTKAEYVFRQGDAEASEILVLHADHVYRFDYGDMIREHRASKAALTVSYQRIERRYVHLFGMVEFDGDGLLTAFEEKPDDPTSDLVFAAFCLFDAATLRRYLEQLRGTDWQHDISRDVIPAMLAGGELIRGYEVKSYWEDIGTVDRYHRAHRGLLRADPTLALSDMPLTVAPEVPRHLVPGGPGRRASVVAADVANEGEIVSSVVYPGARIGVDAHVVDCVVLPGARVPDGTHLASAIVLEDGSVQQCEAEREEVAL