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vjbR

Gene
vjbR
Protein
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Organism
Brucella abortus (strain 2308)
Length
259 amino acids
Function
Transcriptional regulator involved in the global control of Brucella gene expression (PubMed:28334833). Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes (By similarity). Binds with high specificity to a large number of sites distributed across the genome. The VjbR-binding motif contains an asymmetric 16-bp consensus sequence, an unusual feature among LuxR-type regulators (PubMed:28334833). May directly modulate expression of many genes, including virulence determinants, components of the respiratory chain, efflux systems, elements predicted to participate in ion transport and adaptation to stress, uncharacterized proteins, as well as transcriptional regulators probably responsible for the observed indirect VjbR-mediated effects (PubMed:28334833).
Mass
28.625 kDa
Sequence
MSLDLVHFPNYKKTFFGSSFQSDTLALLTRIRDEIGCRYVTHTYRGRVGDCTKVNSADLTVLMTLPATWVARYSSKNYFAIDPVFQEDAPYYRNDTSAIARDLKEDADICPAVAELLHDAEKHGLGNLFIAVSARNPKGVAGCTVFTFEVEDEDRTQFLARMRPRLLSLAGIIHGTVCGCKDANSVASLLTPREVDCLRWAANGKTDGEIAEILSIARWTVVTYLQNAKIKLNCSNRTSAVATALSLGIIDMPEVQHLV

Gene
vjbR
Protein
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Organism
Brucella abortus biovar 1 (strain 9-941)
Length
259 amino acids
Function
Transcriptional regulator involved in the global control of Brucella gene expression. Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes.
Mass
28.625 kDa
Sequence
MSLDLVHFPNYKKTFFGSSFQSDTLALLTRIRDEIGCRYVTHTYRGRVGDCTKVNSADLTVLMTLPATWVARYSSKNYFAIDPVFQEDAPYYRNDTSAIARDLKEDADICPAVAELLHDAEKHGLGNLFIAVSARNPKGVAGCTVFTFEVEDEDRTQFLARMRPRLLSLAGIIHGTVCGCKDANSVASLLTPREVDCLRWAANGKTDGEIAEILSIARWTVVTYLQNAKIKLNCSNRTSAVATALSLGIIDMPEVQHLV

Gene
vjbR
Protein
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Length
259 amino acids
Function
Transcriptional regulator involved in the global control of Brucella gene expression. Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes, including the virB operon and the flagellar genes fliF and flgE, which are activated in the absence of C12-HSL. Regulates virulence factors as well as several membrane structures. Implicated in the control of outer membrane composition. Plays a role in the expression of genes involved in the EPS synthesis and/or export. Mediates the inhibitory effect of C12-HSL on B.melitensis intracellular replication. Could activate expression of ftcR.
Mass
28.625 kDa
Sequence
MSLDLVHFPNYKKTFFGSSFQSDTLALLTRIRDEIGCRYVTHTYRGRVGDCTKVNSADLTVLMTLPATWVARYSSKNYFAIDPVFQEDAPYYRNDTSAIARDLKEDADICPAVAELLHDAEKHGLGNLFIAVSARNPKGVAGCTVFTFEVEDEDRTQFLARMRPRLLSLAGIIHGTVCGCKDANSVASLLTPREVDCLRWAANGKTDGEIAEILSIARWTVVTYLQNAKIKLNCSNRTSAVATALSLGIIDMPEVQHLV

Gene
vjbR
Protein
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Length
259 amino acids
Function
Transcriptional regulator involved in the global control of Brucella gene expression. Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes.
Mass
28.607 kDa
Sequence
MSLDLVHFPNYKKTFFGSSFQSDTLALLTRIRDEIGCRYVTHTYRGRVGDCTKVNSADLTVLITLPATWVARYSSKNYFAIDPVFQEDAPYYRNDTSAIARDLKEDADICPAVAELLHDAEKHGLGNLFIAVSARNPKGVAGCTVFTFEVEDEDRTQFLARMRPRLLSLAGIIHGTVCGCKDANSVASLLTPREVDCLRWAANGKTDGEIAEILSIARWTVVTYLQNAKIKLNCSNRTSAVATALSLGIIDMPEVQHLV

Gene
vjbR
Protein
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Organism
Brucella suis biovar 1 (strain 1330)
Length
259 amino acids
Function
Transcriptional regulator involved in the global control of Brucella gene expression. Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes.
Mass
28.625 kDa
Sequence
MSLDLVHFPNYKKTFFGSSFQSDTLALLTRIRDEIGCRYVTHTYRGRVGDCTKVNSADLTVLMTLPATWVARYSSKNYFAIDPVFQEDAPYYRNDTSAIARDLKEDADICPAVAELLHDAEKHGLGNLFIAVSARNPKGVAGCTVFTFEVEDEDRTQFLARMRPRLLSLAGIIHGTVCGCKDANSVASLLTPREVDCLRWAANGKTDGEIAEILSIARWTVVTYLQNAKIKLNCSNRTSAVATALSLGIIDMPEVQHLV