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virA

Gene
virA
Protein
Limited host range VirA protein
Organism
Rhizobium radiobacter
Length
835 amino acids
Mass
92.444 kDa
Sequence
MTWDRLLPSRKFLLAINSWYVLALVVAAISFAVLAIGPWKNEKSIEAILTELQSIDVDCALLQRNVLRAHAGLLRNYRPLMVPLGRVRSSIANLQQLFKKARVEDVGELSELLARLKSSINTTDAAVASFGAQNVVFEDSLATFNQSISSLLRTSDSRDLNAAKVPELGYLMLQFSFRPNTELALQITQSLDQLQMSTNADKVAIQEVVRNGRVILGVLPRLNETVKLVQASGTFENTKKLQRAYLEADSLARVVEQRVRTFLGAVSVFFCFGIVILVHKLRRRTDRLARRLDFEEVIKKIGVCFEDSTETKQSLKSSAEAALGTIENFFEANQCVLGLVNVTENEIAETFSASAPPPSWNERRIRKIVSLVQADEHGSIFRDYPARKASCFNEDAPGRWALVAFKVSDRLVAVFGLRFDRDPVQPASSEVQLMELAAGCVSHYVVIRCKQTQRDILERRLKHAERLEAVGTLAGGIAHEFNNILGVILGYAMAQNILHRRTYARHYIDRINAESNRARLIIDQILALSRRRERTARPFNLSALVREIAPSLRVALPSEVEVDFNIQSAQMIVEGNPLEIEQILMNLCKNAAEACIGTGRIEDSVYRSFVWKHKVLANGTIPAGDYILLSFEDNGGGIGQAALPHIFEPFFRTRAQCGGTGLGLSTVHGHVSAMAGFVDVISTVGRGTRFDIYLPTSAKKPVNSESFFGPEKIPLGSGEIVAVVEPDPVTLERYEETIAAFGYEPVGFNTFKGLTDWVLAGKEADIVLIDHSSFLDGERVGSWVATLEKVPIIMIGQHQKNVSISADGEASNHFLQKPVSSKALAYVVRANIRTE

Gene
virA
Protein
Wide host range VirA protein
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Length
833 amino acids
Function
Activates VirG, by phosphorylating it, in the presence of acetosyringone or hydroxysyringone.
Mass
91.322 kDa
Sequence
MNGRYSPSRQDFKTGAKPWSILALVVAAMIFALMAITSWQDNETNRAILTQLRAINIDSASLQRDVLRAEAGVVANYRPIISRLGALRKNLENLKRLFKQSHLVIGNDFSQLLDKLKVSVDTTDAAVAAFGAQNVLLQDSLASFTRALSILPKMSSTDQTVENSNELGSLMLRFVRQPSPALSLEISHELDMLQKASGGAEVPIRILAREGRVILSILPRVNDAVNMIQTSDTAEIAERLERKCLEAYSLQSVREQRARIFLGSVSVGLCIYIISLVYRLRRKTAWLTRRLDYEEVIKEIGVCFEGGGATASSLNSSAQAALGIIQRFFNAESCALALVDHGDRWAVESFAAKLPEPVWEDLALREMVSLARADERASVFRIMSTRKVSCLPPETPGVSMLLAHKSTDQLIAICSLGYQGYRLKSCPGEVQLLELATACLCHYIDVRRKQTECDILERRLEHAERLQAVGTLAGGIAHEFNNILGAILGYAEMAQNMLRRSSVTRRHIDQIISSGDRARLIIDQILTLSRKLERVTKPFSVSELVMEIAPLLRVALQRNIELKFKFDDKKSVVEGSPLEVQQMLMNLCKNASQAFTADGQIDIIVSRIFVSRQKVLAHGVMPAGDYVLLSVSDDGEGIAETVLPHIFEPFFTTRSCSGGTGLGLAAVHGHVSALAGYIDVTSAVGRGTRFDIYLPPSSKKPVSPDAFFGPCKTPRGNGEIVALIEPDPVLREVYEDKIAALGYEPVGFKTCADLCNWISKGKQADLVLVDQSSLPENQSATALHAAFKTASIIIGGSDLKMSLSSDDMTSALFLPKPISSRTMAYAIRTKIKA

Gene
virA
Protein
Wide host range VirA protein
Organism
Rhizobium radiobacter
Length
829 amino acids
Function
Activates VirG, by phosphorylating it, in the presence of acetosyringone or hydroxysyringone.
Mass
91.798 kDa
Sequence
MNGRYSPTRQDFKTGAKPWSILALIVAAMIFAFMAVASWQDNATTQAILSQLRSINADSASLQRDVARAHTGTGRNYRPIISRLGALRKNLEDLKQLFRQSHIVSESNAAQLLRQLEVSLNSADAAVRAFGAQNVRLQDSLASFTRALSSLPGKASTDQTLEKPTELASMMLQFLRQPSPAISFEISLELERLQKQRGLDEAPVRILAREGPIILSLLPQVKDLVNMIQTSDTAEIAEMLQRECLEVYSLKNVEERSARIFLGSASVGLCLYIITLVYRLRKKTDWLARRLDYEELIKEIGVCFEGEAATTSSAQAALRIIQRFFDADTCALRLVDHDRRWAVETFGAKHPKPVWDDSVLREIVSRTKADERATVFRIISSKKIVHLPLEIPGLSILLAHKSTDKLIAVCSLGYQSYRPRPCQGEIQLLELATACLCHYIDVRRKQTECDVLARRLEHAQRLEAVGTLAGGIAHEFNNILGSILGHAELAQNSVSRTSVTRRYIDYIISSGDRAMLIIDQILTLSRKQERMIKPFSVSELVTEIAPLLRMALPPNIELSFRFDQMQSVIEGSPLELQQVLINICKNASQAMTANGQIDIIISQAFLPVKKILAHGVMPPGDYVLLSISDNGGGIPEAVLPHIFEPFFSTRARNGGTGLGLASVHGHISAFAGYIDVSSTVGHGTRFDIYLPPSSKEPVNPDSFFGRNKAPRGNGEIVALVEPDDLLREAYEDKIAALGYEPVGFRTFNEIRDWISKGNEADLVMVDQASLPEDQSPNSVDLVLKTSAIIIGGNDLKMTLSREDVTRDLYLPKPISSRTMAHAILTKIKT

Gene
virA
Protein
Wide host range VirA protein
Organism
Agrobacterium tumefaciens (strain 15955)
Length
829 amino acids
Function
Activates VirG, by phosphorylating it, in the presence of acetosyringone or hydroxysyringone.
Mass
91.64 kDa
Sequence
MNGRYSPTRQDFKTGAKPWSILALIVAAMIFAFMAVASWQDNATTQAILSQLRSINADSASLQRDVLRAHTGTVANYRPIISRLGALRKNLEDLKQLFRQSHIVSESNAAQLLRQLEVSLNSADAAVAAFGAQNVRLQDSLASFTRALSSLPGKASTDQTLEKPTELASMMLQFLRQPSPAISFEISLELERLQKQRGLDEAPVRILAREGPIILSLLPQVKDLVNMIQTSDTAEIAEMLQRECLEVYSLKNVEERSARIFLGSASVGLCLYIITLVYRLRKKTDWLARRLDYEELIKEIGVCFEGEAATTSSAQAALRIIQRFFDADTCALALVDHDRRWAVETFGAKHPKPVWDDSVLREIVSRTKADERATVFRIISSKKIVHLPLEIPGLSILLAHKSTDKLIAVCSLGYQSYRPRPCQGEIQLLELATACLCHYIDVRRKQTQCDVLARRLEHAQRLEAVGTLAGGIAHEFNNILGSILGHAELAQNSVSRTSVTRRYIDYIISSGDRAMLIIDQILTLSRKQERMIKPFSVSELVTEIAPLLRMALPPNIELSFRFDQMQSVIEGSPLELQQVLINICKNASQAMTANGQIDIIISQAFLPVKKILAHGVMPPGDYVLLSISDNGGGIPEAVLPHIFEPFFTTRARNGGTGLGLASVHGHISAFAGYIDVSSTVGHGTRFDIYLPPSSKEPVNPDSFFGRNKAPRGNGEIVALVEPDDLLREAYEDKIAALGYEPVGFRTFNEIRDWISKGNEADLVMVDQASLPEDQSPNSVDLVLKTASIIIGGNDLKMTLSREDVTRDLYLPKPISSRTMAHAILTKIKT

Gene
virA
Protein
Cysteine protease-like VirA
Organism
Shigella flexneri
Length
400 amino acids
Function
Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.
Similarity
Belongs to the protease EspG/VirA family.
Mass
44.735 kDa
Sequence
MQTSNITNHERNDSSWMSTVKSTTEVSWNKLSFCDILLKIITFGIYSPHETLAEKHSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFHVKDTDFNSVWHDIYRDIRASDSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV

Gene
virA
Protein
Cysteine protease-like VirA
Organism
Shigella sonnei (strain Ss046)
Length
400 amino acids
Function
Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence (By similarity).
Similarity
Belongs to the protease EspG/VirA family.
Mass
44.706 kDa
Sequence
MQTSNITNHERNDSSWMSTVKSTTEVSWNKLSFCDVLLKIITFGIYSPHETLAEKYSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFPVKDTDFNSVWHDIYRDIRASNSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV

Gene
virA
Protein
Cysteine protease-like VirA
Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Length
400 amino acids
Function
Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence (By similarity).
Similarity
Belongs to the protease EspG/VirA family.
Mass
44.723 kDa
Sequence
MQTSNITNYERNDSSWMSTVKSTTEVSWNKLSFCDVLLKIITFGIYSPHETLAEKYSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFSVKDTDFNSVWHDIYRDIRASDSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV

Gene
virA
Protein
Virulence protein VirA
Organism
Vibrio anguillarum (strain ATCC 68554 / 775)
Length
304 amino acids
Function
Could be involved in the biosynthesis of a major surface antigen important for virulence.
Mass
36.183 kDa
Sequence
MKYPRSLSWEKISSSTISIREFNRFENKKKVAIFCGYVRDKYEFNYHDRTYQWLRNNDYYVILVMPKSGILLESDLCKACDVFIERENFGYDFGSYACGLQYVNLIEGSERIDRLLFVNDSFIGPFGYCNLIEDSSEFWGNTDSNQVKYHYQSYLFGFNLEKVNLDIINNFFFSRGDIYTDDKSLVIENFELSLYEYFNGKGLRCSVLHPISVLKSDFIKQTFHFISYPYLTSKIFFYIMVIARDVNPTHQLWLQLFKRGFPFIKKELLRDNPTGYPELYKKVEEVMGSNDFNGEYKQIFKNHL

Gene
virA
Protein
Virulence protein VirA
Organism
Vibrio anguillarum
Length
304 amino acids
Function
Could be involved in the biosynthesis of a major surface antigen important for virulence.
Mass
36.183 kDa
Sequence
MKYPRSLSWEKISSSTISIREFNRFENKKKVAIFCGYVRDKYEFNYHDRTYQWLRNNDYYVILVMPKSGILLESDLCKACDVFIERENFGYDFGSYACGLQYVNLIEGSERIDRLLFVNDSFIGPFGYCNLIEDSSEFWGNTDSNQVKYHYQSYLFGFNLEKVNLDIINNFFFSRGDIYTDDKSLVIENFELSLYEYFNGKGLRCSVLHPISVLKSDFIKQTFHFISYPYLTSKIFFYIMVIARDVNPTHQLWLQLFKRGFPFIKKELLRDNPTGYPELYKKVEEVMGSNDFNGEYKQIFKNHL