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vgb

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Length
300 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
31.317 kDa
Sequence
MARERTVEIREHEVPDPAGGPYGITAGPDGALWFTLVHSGLIARLAPGGEATTHRLDADSGPAIITAGADGALWFTEHRAHRIGRLTTEDGLTEFAPPTPQAGPYGLATGADGALWFTEASAGRIGRITAEGEIAEFGLPVPGAFPSMIAAGPDDAMWFTANQANAIGRMSFDGTAVLHELPTEAAAPVGLALGPDGALWFTEIGAGQIGRVTADGAISEFPLPDRTSRPHAIVARGDELWFTEWGANRVGRIDLDGRIDVHELPTPNSEPHGIAVGQDGALWVALENGALARVAPESHD

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
Length
299 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
31.135 kDa
Sequence
MNQVEMTEFPVGKPQEALYGVASTPDGALWFTLAKGNAIGRLSPDGAVSRFPLPHADGQPTTITCGPDGRPWFTLSSANAIGRLAPDGALRMFELPRPASRPFGIAGGHDGCLWFAEMAGDRIGRITIDGDIEEYDLPVKGGYPSCMAAGRDGLMWFTLNQAGAVGSISATAAPRIFPLGAADAAPVGIASDAQGALWIAQAGNGAIARFDAGGRITEFPLHSRAARPHAIAADAAGNLWFTEWGANRIGRISEAGDLAGYELAAPGSEPHGIAIDPHGCVWAALETGRLVRLQASPRD

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Length
299 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
31.193 kDa
Sequence
MNQVEMTEFPVGKPQEALYGVASTPDGALWFTLAKGNAIGRLSPDGAVSRFPLPHTDGQPTTITCGPDGRPWFTLSSANAIGRLAPDGALRMFELPRPASRPFGIAGGHDGCLWFAEMAGDRIGRITIDGDIEEYDLPVKGGYPSCMAAGRDGLMWFTLNQAGAVGSISATAAPRIFPLGAADAAPVGIASDAQGALWIAQAGNGAIVRFDAGGRITEFPLHSRAARPHAIAADAAGNLWFTEWGANRIGRISEAGDLAGYELAAPGSEPHGIAIDPHGCVWAALETGRLVRLQASPRD

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Length
299 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
31.143 kDa
Sequence
MNQVEMTEFPVGKPEEALYGVASTPDGALWFTLAKGNAIGRLSPDGEVSRFPLPHADGQPTTITCGPDGRPWFTLSSANAVGRLSPDGALRMFELPRPASRPFGIAAGHDGCLWFAEMAGDRIGRITIDGDIEEYDLPVKGGYPSCMAAGRDGLMWFTLNQAGAIGSISATAAPRIFPLGAADAAPVGIASDAQGALWIAQAGNGAIARFDAGGRITEFPLHSRAARPHALAADAAGNLWFTEWGANRIGRISEAGDTAGYELAAPGSEPHGIAIDPHGCVWAALETGSLVRLQASPRD

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Staphylococcus aureus
Length
299 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
33.058 kDa
Sequence
MEFKLQELNLTNQDTGPYGITVSDKGKVWITQHKANMISCINLDGKITEYPLPTPDAKVMCLTISSDGEVWFTENAANKIGRITKKGIIKEYTLPNPDSAPYGITEGPNGDIWFTEMNGNRIGRITDDGKIREYELPNKGSYPSFITLGSDNALWFTENQNNAIGRITESGDITEFKIPTPASGPVGITKGNDDALWFVEIIGNKIGRITPLGEITEFKIPTPNARPHAITAGAGIDLWFTEWGANKIGRLTSNNIIEEYPIQIKSGEPHGICFDGETIWFAMECDKIGKLTLIKDNME

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
299 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
31.124 kDa
Sequence
MNEINESYDTDSVREFTVSDADAGPYALAEGPDGALWFTLVHRGAVARRDPDDGRVTVHPVGDGPTVIAPGPDGALWFTEYRAHRIGRITPEGHYASFAPLTPEGGPFGITAGPDGAMWFTLSSADRVGRVTMDGEVTEHPAPGAFPSALTAGPDGALWCTLNQGNAIGRLTPDGHGTAYPLPTPGAAPVGIAAGPDGALWFTEIGAGRIGRITVTGDLTEYPLSDPAARPHAVTAGPNGALWFTEWGSGRVGRITVDGRVTSYPLSRTDCEPHGIAVHDGALWCALETGSLARIQVPA

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Bacillus weihenstephanensis (strain KBAB4)
Length
296 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
32.484 kDa
Sequence
MRITIQEYVVNEIDSGPYGITVGKDGALWFTEQKGNRIGRINATGEINSFPIPTANAGAMSIISDQTGDLWFTEYNSSKIGKMSMNGLFEEYVLPTTNAAPFGITEGPDGAIWFTEMNNGRIGRITKSGEITEFELPNSKSFPSFITLGSDGALWFTQNQNNRIGRITTKGEVKEYPIPTPNSGPVGIASGPDGAIWFVQIIGNKIGRITFEGEIKEFVIPTPNARPHAIIPGKNRDLWFTEWGGNQISRITVEGVITEYTIPTNNAEPHGITFCPDGDLWFAEECNQIGRLTIIT

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Length
295 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
31.344 kDa
Sequence
MQIRMTEYQVPDPESGPYGITVCANGRIWFTEQKGNRIGMLTESGDITEYTIPTESAGASIITSGIDGELWFTEYKAGKIGKITPQGKITEYALPPGAAPFGIAAGCDDAMWYTDMAGHQIGRLSSSGEITEYKLPKPGAFPSFITRGADGALWFTQNQSGSIGRITADGDISEYPLPQEQSGPVGITAGPDGALWFTEINANQIGRITVSGKISEYQLPTAHARPHAIAAGGDGALWFTEWGAGQIGRITVDGDITEYPIPTADSEPHGIAAGSAHSIWFAEECGRIGKISIQN

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)
Length
295 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
31.857 kDa
Sequence
MNIKINEYYIPTSLSGPYGITAGIDEALWFTENKANKIGRITVKGEIEEYLVPSQDAGLSIIVSGTNGDLWFSEYNANKIGKITIKGEIVEYSIPTADSGPFGITEGPDGAIWFTELTGNKIGRISNLGEVIEYKLPNDSSYPSSIVCGSDGVLWFTENQGNKIGKITMLGEITEYTIPTIGSGPVGITSGPDGALWFVEINGNRIGRITTEGIINEYDLKTVKARPHAIITGSDGALWFTQWGSNQIGRITTSGEVSEYEIPTANSEPHGIAVGPDKAIWFAEECNKIGQLILL

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Length
290 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
30.073 kDa
Sequence
MIPRVTSTAQTDLTEGADPYGICAADDGALWVTLVHSGAVVRLSADGGRRDYPIGAQARPSVVTVGRDGTAWFTRTGDDRITALDRTGAMTTFELASGSGPFGICVGADGAVWFTESTGDRLGRIDPDATVSYVALPEGCFPAFVAAGADGAVWATLNHADAVVRILPSADPEVIDIPTPGAAPVGITWGGDAVWFVEIATGRIGRIGDDRLVTEFALPDPACRPHAITAGPDGCWFTEWATDRVGHIGRDGTVEEYDLPSSVSEPHGITVAPDGAVWVAAESGSVVRLG

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
282 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
29.009 kDa
Sequence
MSKALKVGLDGGPYALAAGPDGAMWVTLAHSGEIARVTETGEVAVYPVAPQARPSIIAAGPDGAMWFTRAGDDRIGRITVDGELAEFELAEGSAPFGIAAGPDDALWFTAMTSGEVCRISTDGEVTSVAVVGGMPSMITAGPDGAMWFTINQGNAIGRLETDGTLTVRELPTPAAGPVGITATHDDAVWFTEIGADQLGRIPLDEAIQELELPGKPHAVVADPDDGVWVSLWGADQLARVSGDGEVVTIDLPSGSEPHGLAIGPDGAAWVALECGFVLRMPN

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Mycobacterium sp. (strain JLS)
Length
280 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
28.959 kDa
Sequence
MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAGELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGETSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRDGVTMRELPTRGAGPVGITATHDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSADGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Mycobacterium sp. (strain KMS)
Length
280 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
28.958 kDa
Sequence
MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAGELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRDGVTMRELPTRGAGPVGITATHDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSADGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Mycobacterium sp. (strain MCS)
Length
280 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
28.958 kDa
Sequence
MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAGELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRDGVTMRELPTRGAGPVGITATHDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSADGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD

Gene
vgb
Protein
Virginiamycin B lyase
Organism
Nocardia farcinica (strain IFM 10152)
Length
279 amino acids
Function
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
Similarity
Belongs to the Vgb family.
Mass
28.848 kDa
Sequence
MPEILEVVDVDGGPYGVTVDETGTLWFTLAARGAVGRLVDGTVETVALEPADGSPTVIMAEGDGAWFTEFRGNRIGRVEANGALSFLTAESPYGLCRAGDGGLWYTELSAGGVVHRAPDGTTTRHAVEGMPSMIAEAADGTVFVTLNQGNAVARITPDGQVRTTALPTAGAGPVGLATAADGAWFVELLAGQLGHVDRDGTVTEHPLPDRDARPHAVVVAPDGTVWFTEWAAARLGRRTADGEITELALPGAEPHGLAVAPDGTLWVAMESGALVHVRP