Protein
Ventral anterior homeobox 2a
Function
Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated tcf7l2 isoform that cannot bind ctnnb1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina.
Similarity
Belongs to the EMX homeobox family.
Sequence
MFDQATSMGDGVSEERSPLCGKSATSCSERVRDKGTRADLECSLRGHSLKDIPVTSTSSPGSSKEEVQDSQSTGEADYCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLELEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDSEKRSSSTSESFATCNILRLLEQGRLLSVPAPPNLISSSQNNMGTSSGNGTNLGTSGSTSPIISTTPPGAGAFSLQVPSLAASSSPRLPTSLCFPGPLLGGLHEIPSGYGLGSSAFEPYTRLDRKDTASSKKSTS