Protein
Vacuolar proton translocating ATPase 100 kDa subunit
Organism
Dictyostelium discoideum
Function
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Required in both the contractile vacuole system and the endosomal/lysosomal system. Also required for cytosolic pH regulation.
Similarity
Belongs to the V-ATPase 116 kDa subunit family.
Sequence
MSFLRPSIWRSSPMQMVQLFVQIEAAHDTVDELGKLGLIQFLDDNEHVNLFQRNFVNEVKRCDDMEKKLKFFEDQVKKEPKLQKLLPDNMLSVVDDDSQMDELEGRFDELESELKQVNANQETLQRNYNELIQLRHVLTKDSVFFQENPNLIEGEGHEHSARSPLLAEDQHVSEVAKQGVKLGFITGVMNTDKMPQFQRSLWRTTRGNNYVKDARIEEEIIDPQTGEETAKTVFIVFFQGERLQQKIKKICESFGANIYDCPDNSFERSNLLQKVTVRITDLYEVLQRSKDHKRQTLAGIVPRLYSWKKKVLLEKSIYHTMNLFDYDVGRKCLIAKGWTPKDKIEEIQLALRTATTRSGALVPSVLSIIKTEGSPPTHFETNKYTSSFQEIVNAYGIAHYREVNPAVLTIVTFPFLFGVMFGDVGHGALLLLSALGLISLEKKLAGKKLNELIQMPFDGRYVLFLMSLFSIYVGFIYNECFSIPMNIFGSQYNLNSTTGLYTYQHTDRVYPVGVDPLWKGAPNELVYYNSFKMKLSIIFGVVQMSVGICFSLLNYLNQKGPIKIVNILTQFVPQMIFLWSIFGYMSVLIILKWVVPYRSFEVDKVDPPFILPTIIAMFLSPGGTPDVVFFSGQGAVQTALLFLALISIPVMLVIKPLFMKRFHFQEVERKKLGHHEEEHDDEALYTGHHGEEFEMGEVFVHQVIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFWERILIGQVERGNPFLAFVGFGAWLGASVAVLLLMESLSAFLHALRLHWVEFQNKFYIGDGVRFIPYSATRILSEDDE