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v1g194069

Gene
v1g194069
Protein
Protein adenylyltransferase Fic
Organism
Nematostella vectensis
Length
427 amino acids
Function
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-204 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of Hsc70-3/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of Hsc70-3/BiP, thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from Hsc70-3/BiP, leading to restore HSPA5/BiP activity (By similarity).
Similarity
Belongs to the fic family.
Mass
48.496 kDa
Sequence
MDSTQIKQGNLRYLIHLLLASLAGLSIAIIVTHAPVFWRLRSSKNTLDPPGFREGLNMLIPEIHFDAEVQDPLYGEALAALKAASAMKHGGKHSKAVKLFQQAVSLAPHHPEILLQYGEFLEQHDVVQAEHLYNRALTANPLDSRALANRQRALPKVKQLDQEMLDKIDEKRDKLFSIPAGSLPMKRAIKEAYFQHIYHSNAIEGNTMTLSMTRAIVETKMAVPGKSILEHNEVLGLDEALKYVNSTLIQKSESITIDDIIEIHRRVLGHAHPLEAGRYRSTQVFVSDHVPPAPEDLEKQMNAFNDWLLSKDPEILHPIEFAALSHYKLVYIHPFTDGNGRTARLLMNAILMRAGFPPVIIRFQDRHDYYEYLNQANHGDIRPFIRFVARCTERTIDAYLASTTIYPLGHERTRELTDAHDEKDPNR