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v1g113105

Gene
v1g113105
Protein
N.vectensis toxin 1 7
Organism
Nematostella vectensis
Length
85 amino acids
Function
Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. Is highly active on DmNav1/TipE (drosophila) and is only extremely weakly active on rat Nav1.4-beta-1/SCN4A-SCN1B, and on human Nav1.5-beta-1/SCN5A-beta-1. Has no activity on the rat brain channel Nav1.2a-beta-1/SCN2A-SCN1B. This reveals high specificity for insect over mammalian channels.
Similarity
Belongs to the sea anemone sodium channel inhibitory toxin family. Type II subfamily.
Mass
9.306 kDa
Sequence
MTSFKIVIVCLALLVAVASARSRDMMSDDERDYHFSKRGIPCACDSDGPDIRSASLSGIVWMGSCPSGWKKCKSYYSIVADCCNQ