Protein
Postreplication repair E3 ubiquitin-protein ligase rad18
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
Similarity
Belongs to the RAD18 family.
Sequence
MDVFGDEAFNVPDSTDWLGTPLACLMPVEQAFRCHVCKDFYDSPMLTSCNHTFCSLCIRRCLSVDSKCPLCRATDQESKLRGNWALREAVEAFKNSRKVLLEFARTPPTIQAILPDQAGPSSPSKRKATEMEGPKEEDPESKRPRRSTRSTRARAAELTAAILQEEQDTTPSADPDYVDQPPDDGLVACPICLTRMKEQQVDRHLDTSCPGSPQAASKRRPIPAQTPQPSTFPSFNTRLTSQTNQKPPERLPALAYSMLRDTALRKKLSELGLSTHGSRQLLEKRHKEWITLWNANCDSSRPKKRSELLRDLDEWERTVGNPGTAAGGGGGQQGLGLMARAQATGAQIKDKEFDGKAWATRYGGSFGDLIKQARQGIKRQTLDGNGEKADTKGGGGGEDVGPAELPTLQAREGESSAAPTRMDIVPPSSPPRPGQVDDADTEHDGQAPGKDAIAEDTAMREQVIPGTPDKERQWETSQQQQPPIPGDAQLSGMKKPNPETC