Protein
Ubiquitin carboxyl-terminal hydrolase 44-B
Function
Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity).
Similarity
Belongs to the peptidase C19 family. USP44 subfamily.
Sequence
MDKCKHVGRLRLAQDHSILNPQKWHCVDCNTTESVWACLSCSHVACGRYIEEHALRHFQDSKHPLALEVNELYVFCYLCDDYVLNDNTTGDLKLLRSTLSAIKSQNYDCTTRSGRTLRSMVSADDSFISHEGAQAFLQNEDRAFTALWHRRHALLGKVFRSWFALTPKGKQRLEEERLREEAEHKREEARKRRQQLKHKLKEEMESTPPRKSSRLQQQIQPSPKIESSSVQKMNQKNAPSTKQNPPAPTSDKARLKKIGNSPIKRKPTVTPGVTGLRNLGNTCYMNSILQILSHLHVFRECFLQLDLNQTQELLAADGSGKTRLSSKYPPGAELPRVTQKHTKGQRSLARRPSFSLGLSGGASNSRNMELIQPKEPSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFHGYAQQDAQEFLCELLDKVQQELETTGTRYPALIPTSQRKLIRQVLNVVNNIFHGQLLSQVTCLVCDHKSNTIEPFWDLSLEFPERYHFSGKATASQRPCLLTEMLAKFTETEALEGKIYACDQCNKAQKQLMVCRLPQVLRLHLKRFRWSGRNHREKIGVHVRFDQMLNMEPYCCRESTAALRADCFIYDLSSVVMHHGKGFGSGHYTAFCYNPEGGFWVHCNDSKLHSCAVEEVCKAQAYILFYTQRVTQENGHLSERLPLHDSPQSPPP