urdA

Urocanate reductase

812 amino acids

Catalyzes the two-electron reduction of urocanate to imidazole propionate (also named deamino-histidine or dihydrourocanate). Imidazole propionate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria L.plantarum strain WCFS1, may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite imidazole propionate.

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

87.232 kDa

MKFVGIVGTNAQHSYNRMLLEFMQRHFATQAEIEILELTDVPMFDESNDQTDSTIIQNFATKIATADGVIIASPEHNHSVPSALKSIIEWLSFKIHPLDGQAVMIVGASYSVQGSSRAQLHLRQILDAPGVNASVMPGSEFLLGRAQTAFDDQGNLKVQGTVDFLDSCFAKFQKFATIVAEMRAPEALSFAPGTYQVTATGHNGELPMRVTLSADRIENIEIDTSSETQGIADVAFERIPKEIIAGQTLAVDAISGASITSHGVIDGVARAVKEAGANPDDLKKRRATKQVAQPAVKEVTTDVVVVGAGGAGMTAAAKVLQAGHQAVVLEKFPAVGGNTVRAGGPMNAADPDWQRQFAALPGEKQTLKDLSERDESTIAPEYRADFRKLKQQIDAYLTANTNQKGTLFDSTLLHRIQTYLGGQRTDLNGQEIHGQYDLVKELTDNALDSVKWLQSIGVKFDESQVTMPVGAIWRRGHKPMGDLGFAYIKTLRAFVEQQGGTIMTETPVKELLVTDGQVRGVIATNAAHEKVIVHADAVILASGGFAANTKMLQKYNTYWTAIDDDVKTTNSPAMTGDGIRLGTSVGAALVGMGFSQMMPVSDPETGELFSGLQVPPANFVMVNQQGKRFVNEYGSRDELTQAAIDNGSLFYLIADDEIKKTAYNTTQAKIDQQVANGTLFRADTLTDLAQQIGMDPAALTKTIADYNRYVDAGEDPEFHKTAFDLKVAVAPFYATPRKPATHHTMGGLKIDSDAHVLNTDGQVIDGLYAAGEVAGGIHAGNRLGGNSLSDIFTFGRIAAAHAVAEHVDPVTA

urdA

Urocanate reductase

803 amino acids

Catalyzes the two-electron reduction of urocanate to imidazole propionate (also named deamino-histidine or dihydrourocanate). Imidazole propionate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria S.parasanguinis strain ATCC 15912 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite imidazole propionate.

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

86.939 kDa

MKLVAIVGTNAKQSYNRSLLQFMQRHFATKADIEILEITDVPMFNETDDQTDTPVIQKFNQAISEADGVIISTPEHNHTIPSSLNSLIEWLSFNIHPLDGKPTMIVGASYDVQGSSRAQLHLRQILDAPGVNATVMPGSEFLLGRAHRAFDENGDLIDERTVDFLDSCFYRFLRFVSVANQLNLPEEIRFEPGTYHVTTEGHNGKLPMDVTVSEDRIEKIEIDSSGESSGIADVVFTRIPAEIIEGQTLNVDAVSGASVTSNGVLDGVARAVKQAGANPDVLRKRSKAPSALDKEDKTYQADVVIVGGGGAGLAAAAAVLQAGKKPIVVEKFPAIGGNTVRAGGPMNAPDPAWQGTFEAHPGEANTLQELIAIDESTIDPEYLEDFRALKVEVEQYLQDPSYLFDSTLLYRIQTYIGGKRKDLQGHEIHGQYDLVSVLTERALESVRWLEDIGVEFVRSEVTMPVGALWRRGHKPVQPMGYAFISVLQKYVLENGGKILTDSPVKELLVEEGTVKGVRAEGRNGQTILVHADAVVLASGGFGANTKMLQKYNTYWTEIADDIATSNTPAVTGDGILLGQSVGADLVGMGFSQMMPVSDPVTGALFSGLQVPPANFIMVNTEGKRFVDEYGSRDKLSQAAIDNGGLFYLIADDRIKATAYNTSQEKIDAQVKAGTLYRADTIEELAVQIGMDPQVLADTIKKYNSYVDAGFDPEFNKGSFDLKCEVAPFYATPRKPAVHHTMGGLKIDTSTHVLNEKGQIIPGLYAAGEVAGGLHAGNRLGGNSLTDIFTFGRIAGQTAVKENC

urdA

Urocanate reductase

803 amino acids

Catalyzes the two-electron reduction of urocanate to imidazole propionate (also named deamino-histidine or dihydrourocanate). Imidazole propionate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria S.mutans strain UA159 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite imidazole propionate.

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

86.809 kDa

MKLIAIVGTNAKQSYNRILLQFMKRHFVQKADIDIMEIANVPMFNETEDQTDLPAIQNFNTKISQADGVIIATPEHNHTIPSSLNSLLEWLSFKVHPLDGKPLMIVGASYDVQGSSRAQLHLRQILDAPGVNAAVMPGSEFLLGRAHQAFDEAGNLKSEATVDFLESCFFKFLRFVQVANQLNEPEEVSFEAGTYQVTTQGHNGKLPMTVTLSEEKIEKIDIDSSGESSGIADIVFTRIPNEILEGQTLNVDAVSGASVTSNGVLDGVARAIKLAGGNPDVLRKRPKAPSALDKEDKTYSTDVVIVGGGGAGLAAAARVLQAGKQVMVLEKFPALGGNTVRSGGLLNAADPEWQKTFPANPGEAHNLSELIQTDEDSIAAEYLADFKELKQQVTNYLKDPSYLFDSNILHRIQTYIGGKRTDRNGCEVYGNYDLVKVLTDKDLDSVHWLADIGVDFDRSEVSMPVGALWRRSHKPKQPMGYAFIEALDTYIRKNSGTILTDTAVTDFILENGLIKGVLAKGRNGQTITVHAQAVVLASGGFGANTKMLQQYNTYWSNIDDNIQTTNSPAITGDGIRLGQSIGAALVGMGFSQMMPVSDPNTGAIFSGLQVPPANFVMVNQEGKRFVDEYGSRDTLSKAAIDNGGLFYLIADENIKATAMNTSNEKIEEQVAAGTLYRADTLESLAEQIGVDPATLVETINNYNSYVEAGYDPEFDKGAFDLKVEKAPFYATPRKPATHHTMGGLKIDTQAHVIKEDGNKIPSLYAAGEVTGGIHAGNRLGGNALADIFTFGRIAAETAVTECC

urdA

Urocanate reductase

617 amino acids

Catalyzes the two-electron reduction of urocanate to imidazole propionate (also named deamino-histidine or dihydrourocanate). Imidazole propionate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria L.fermentum strain NBRC 3956 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite imidazole propionate.

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

66.121 kDa

MKAGTYKVKAKGHGSSFMPMEVTLSDDAIQRIQVDASGETSGIADEVFKRLPAKIVKGQTLNVDTVAGATISSRGVVGGVAEAITLAGGDADEWKQRAKPEIATQAAQVEEYQTDVVVVGAGGAGLAAATRSLQHDKQVVILEKFPQLGGNTTRAGGPMNAADPDWQRDFAALTGEKETLKRLANTPLEQIDPEYRADFERLREQIKEYIASGAQYLFDSNLLHEIQTYLGGKREDLAGHEIHGRYQLVKTLVDNALDSVKWLADLGVKFDQTDVTMPVGALWRRGHKPVEPMGYAFIHVLGDWVTEHGATILTETRAEHLLMENGRVVGVVAHKTDGTKVTVRAKSTFLTAGGFGANTPMVQKYNTYWEHIDDDIATTNSPAITGDGISLGQEAGAELTGMGFIQLMPVSDPVTGELFTGLQTPPGNFIMVNQEGKRFVNEFAERDTLAAAAIAQGGLFYLIADDKIKETAYNTTQESIDAQVEAGTLFKADTLAELAGKVGMDPATLEDTINKYNSYVDAGHDPEFGKSASHLKCEVAPFYATPRKPAIHHTMGGLAIDKHGHVLDKAERVIAGLYSAGENAGGLHAGNRLGGNSLADIFTFGRLAADTAAQENG

urdA

Urocanate reductase

606 amino acids

Catalyzes the two-electron reduction of urocanate to imidazole propionate (also named deamino-histidine or dihydrourocanate). Imidazole propionate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria E.lenta strain DSM 2243 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite imidazole propionate.

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

63.494 kDa

MSNLSRRNFITGGAIAALGGTLAIAGCAPKGESSSTVAGAAGEGAQAWTGTANGKGGELTVEVITEGDSIARINPLKSRESYGVGTAGIDVLSDLIVKNQTLNVDMVTGATVSSMAFLTAVSDAVDASGMKSSEWKKREKAVPQAPEGLTTDVDVVVVGAGGAGYAAALTAAEAGKNVVLLEKLGIVGGDTILSGGAMAVPNNWFQKRDGIEDSVEKMAEDMIVGGDHVGDPDLVNVICEGAYGAMEWLIFNGGVAWQPYERFFGGHSVIRSLIPEGNEGSGIICKLDKRAEGLKNLKVCRNTKADELVQDASGAVVGLKATNTATGETYDFKAKAVILAAGGFGSNVEMRMKYNPEMDEKILSTDSVGATGDCHVMAEKIGANLIDMQYIQTYPTCDTQTGALLYVGNMRLENRAICINKEGDRFVEEMERRDVISNAIKEQTDGIGYMIFNQDGLDHTDIATVNAAEMDGLFGRGQLAKGETIAEACEPFGIDAAELQKTVEKWNGYCKDGADPDFNYRAALNPIEGGPYYILAYKPSVHYTMGGLHINTDAQVLDSDAAPIPGLFAAGEQAGHKMGTNRLGSCSITDVFVFGRVAGANAAALA

urdA

Urocanate reductase

582 amino acids

Catalyzes the two-electron reduction of urocanate to deamino-histidine. The physiological electron donor is unknown; it might be the membrane-bound tetraheme cytochrome c (CymA). Enables anaerobic growth with urocanate as a sole terminal electron acceptor, and thus can provide the cells with a niche where no other bacteria can compete and survive. Is unable to reduce cinnamate and other unsaturated organic acids such as acrylic, crotonic, fumaric and orotic acids. Has no fumarate reductase or succinate dehydrogenase activity.

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

62.235 kDa

MHYKKSIIGIAVTATAIIAGCQVTHQIVKSQGTAQGKHGEVQVETTFKDGHIVAIDVLKQKENKVLAGAVFKDVKQAIIDNNSIEVDGIAGATVTSKALKEAVGKSIEAAGVTLVATASAKKSEALTPAEYTYDVVIIGSGGAGFSAGLEAIAAGRSAVIIEKMPIIGGNSLISGAEMNVAGSWVQKNMGITDSKELFISDTLKGGDFKGDPEMVKTMVDNAVGAAEWLRDYVKVEFYPDQLFQFGGHSVKRALIPKGHTGAEVISKFSIKADEVGLPIHTNTKAEKLIQDQTGRIVGVEAAHNGKTITYHAKRGVVIATGGFSSNMEMRKKYNPELDERYGSTGHAGGTGDGIVMAEKIHAAAKNMGYIQSYPICSPTSGAIALIADSRFFGAVLINQKGERFVEELERRDVISHAILAQPGRYTYVLWNQDIENVAHTVEMHQGELKEFTKDGLMYKVDTLEEAAKVFNIPEDKLLSTIKDVNHYAATGKDEAFNHRSGLVDLSKGPYWILKATPSVHHTMGGLVVDTRTRVLDEQGKVIPGLFAAGEVTGLTHGTNRLGGNAYTDIIVYGRIAGQEAAK