Protein
Orotate phosphoribosyltransferase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Similarity
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Sequence
MAALSPYKADFLKASIDGGVLKFGSFELKSKRISPYFFNAGDFYRADLLQAISTAYAKCIIEAHKSGQLDFDIVFGPAYKGIPLATAATDKLAQLDPETYGKICYSFDRKEAKDHGEGGNIVGAPLKGKRILIVDDVITAGTAKREAIAKIEKEGGIVAGIVVALDRMEKLPAADGDDSKPGPSAMGELRKEYGIPIFAILTLDDIIEGMRGLASPEDVEKTEEYRAKYKATD