Protein
Homeobox protein unc-4
Organism
Caenorhabditis elegans
Function
Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth.
Similarity
Belongs to the paired homeobox family. Unc-4 subfamily.
Sequence
MIGALHACVDAEPKIINDIWADFWKSQINSVLLNPSDGSETYLASDNGKSTSSREQSTSPDDDNLLMNEDDGIALEDDNDTGESAAKRRRTRTNFSGWQLEELESAFEASHYPDVFMREALAMRLDLLESRVQVWFQNRRAKWRKREQNRNGSSEIKKDDGEQMETKALPTFPFSIDSILAVSRVPRGRRPNAKYPRVQACKNLSPFMIPLFPITQPGGNVIREKSPPLPTQQSQIVATNALTTVAELLKSV