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un-4

Gene
un-4
Protein
Mitochondrial import inner membrane translocase subunit tim16
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
141 amino acids
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (hsp70-5) via its interaction with tim14/pam18. May act by positioning tim14/pam18 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Similarity
Belongs to the TIM16/PAM16 family.
Mass
15.805 kDa
Sequence
MAYRLITQVVVVGSRVLGRAFAEAYKQAAASSQYQRAQQKNGNAATGRASLTSGMTLDEACKILNVNKPADGTAANMEEVMERFKRLFDANDPEKGGSFYLQSKVVRARERLEAEIKPKMEEKQAEEEVKEGWNPKIYKDR