Function
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:16324156, PubMed:16387300). Shown to facilitate the reduction of insulin disulfide bonds (PubMed:16324156, PubMed:16387300). Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide (PubMed:30014846). Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to a NO stimulus, whereas de-nitrosylation activity might promote calcium flux when NO is diminished (PubMed:30014846). By regulating the NO-induced ASJ sensory neuron activity, mediates the avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846). Positively regulates life span extension under normal and caloric restriction conditions, dauer formation and the oxidative stress response (PubMed:16387300, PubMed:16324156, PubMed:21334311, PubMed:21304598, PubMed:26920757). Contributes to the down-regulation of expression of the insulin-like neuropeptide daf-28 in the ASJ neurons in a redox-independent fashion, thereby promoting dauer formation (PubMed:21304598). Negatively regulates the nuclear localization of the intestinal skn-1 transcription factor in a p38 MAPK pathway-dependent and redox-independent fashion (PubMed:26920757).