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triap1-b

Gene
triap1-b
Protein
TP53-regulated inhibitor of apoptosis 1-B
Organism
Xenopus laevis
Length
78 amino acids
Function
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The triap1:prelid1 complex probably functions as a phosphatidic acid (PA) transporter across the mitochondrion intermembrane space to provide PA for cardiolipin CL synthesis in the inner membrane. Likewise, the triap1:prelid3a complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (By similarity). Required for pronephros development; probably involved at an early stage in the formation of pronephric components derived from the somatic layer (By similarity).
Similarity
Belongs to the TRIAP1/MDM35 family.
Mass
8.882 kDa
Sequence
MNSVGEECTDMKREYDQCFNRWFAEKFLKGDGSGDPCTELFRRYRECVQKAIKDKDIPVDGVDFMGPSKSKTEADGSS